methyl N-Cbz-3,5-dibromo-N-methyl-L-tyrosyl-3,5-dibromo-N-methyl-L-tyrosinate

Base Information

Chemical Name:methyl N-Cbz-3,5-dibromo-N-methyl-L-tyrosyl-3,5-dibromo-N-methyl-L-tyrosinate
CAS No.:108969-77-3
Molecular Formula:C₂₉H₂₈Br₄N₂O₇
Molecular Weight:836.167
Hs Code.:

Synonyms:methyl N-Cbz-3,5-dibromo-N-methyl-L-tyrosyl-3,5-dibromo-N-methyl-L-tyrosinate

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Chemical Property of methyl N-Cbz-3,5-dibromo-N-methyl-L-tyrosyl-3,5-dibromo-N-methyl-L-tyrosinate

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Technology Process of methyl N-Cbz-3,5-dibromo-N-methyl-L-tyrosyl-3,5-dibromo-N-methyl-L-tyrosinate

There total 5 articles about methyl N-Cbz-3,5-dibromo-N-methyl-L-tyrosyl-3,5-dibromo-N-methyl-L-tyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 108969-87-5
2,6-dibromo-N-methyltyrosine methyl ester

: 108969-86-4
N-benzyloxycarbonyl-2,6-dibromo-N-methyltyrosine

: 108969-77-3
methyl N-Cbz-3,5-dibromo-N-methyl-L-tyrosyl-3,5-dibromo-N-methyl-L-tyrosinate

Guidance literature:: With dicyclohexyl-carbodiimide; In 1,4-dioxane;
DOI:10.1021/jo00389a068

Reference yield:

: 537-49-5
N-methyl-L-tyrosine

: 108969-77-3
methyl N-Cbz-3,5-dibromo-N-methyl-L-tyrosyl-3,5-dibromo-N-methyl-L-tyrosinate

Guidance literature:: Multi-step reaction with 3 steps

1: Br₂ / methanol / Ambient temperature

2: conc. H₂SO₄ / 46 h / Heating

3: 57.5 percent / N,N-dicyclohexylcarbodiimide / dioxane / 1 h / Ambient temperature

With sulfuric acid; bromine; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol;
DOI:10.1248/cpb.43.1325

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 108969-77-3
methyl N-Cbz-3,5-dibromo-N-methyl-L-tyrosyl-3,5-dibromo-N-methyl-L-tyrosinate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / K₂CO₃ / acetone; H₂O / 0.5 h / Ambient temperature

2: 100 percent / Br₂ / CHCl₃; H₂O / 0.17 h / Ambient temperature

3: 57.5 percent / N,N-dicyclohexylcarbodiimide / dioxane / 1 h / Ambient temperature

With bromine; potassium carbonate; dicyclohexyl-carbodiimide; In 1,4-dioxane; chloroform; water; acetone;
DOI:10.1248/cpb.43.1325