2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid

Base Information

Chemical Name:2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid
CAS No.:150933-14-5
Molecular Formula:C₁₉H₂₈F₂NO₇P
Molecular Weight:451.404
Hs Code.:

Synonyms:2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid

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Chemical Property of 2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid

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Technology Process of 2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid

There total 7 articles about 2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 150933-22-5
2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid methyl ester

: 150933-14-5
2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid

Guidance literature:: With lithium hydroxide; at 0 ℃;
DOI:10.1016/S0040-4039(00)60508-7

Reference yield:

: 81172-89-6
terephthalaldehyde mono(diethylacetal)

: 150933-14-5
2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1) NaH / 1) THF, 0 deg C, 2) 0 deg C

2: 50 percent / NaOMe / methanol / 1 h / 0 °C

3: 95 percent / H₂ / 10percent Pd/C / methanol

4: 93 percent / tetrahydrofuran

5: 1) oxalyl chloride, DMSO, 2) NEt₃ / CH₂Cl₂

6: 62 percent / DAST

7: 96 percent / LiOH / 0 °C

With lithium hydroxide; oxalyl dichloride; hydrogen; sodium methylate; sodium hydride; dimethyl sulfoxide; triethylamine; 4,4'-diaminostilbene-2,2'-disulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(00)60508-7

Reference yield:

: 150933-17-8
[(4-Formyl-phenyl)-hydroxy-methyl]-phosphonic acid diethyl ester

: 150933-14-5
2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 50 percent / NaOMe / methanol / 1 h / 0 °C

2: 95 percent / H₂ / 10percent Pd/C / methanol

3: 93 percent / tetrahydrofuran

4: 1) oxalyl chloride, DMSO, 2) NEt₃ / CH₂Cl₂

5: 62 percent / DAST

6: 96 percent / LiOH / 0 °C

With lithium hydroxide; oxalyl dichloride; hydrogen; sodium methylate; dimethyl sulfoxide; triethylamine; 4,4'-diaminostilbene-2,2'-disulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(00)60508-7