2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid methyl ester

Base Information

Chemical Name:2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid methyl ester
CAS No.:150933-22-5
Molecular Formula:C₂₀H₃₀F₂NO₇P
Molecular Weight:465.431
Hs Code.:

Synonyms:2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid methyl ester

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Chemical Property of 2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid methyl ester

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Technology Process of 2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid methyl ester

There total 6 articles about 2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 150933-21-4
2-tert-Butoxycarbonylamino-3-[4-(diethoxy-phosphoranecarbonyl)-phenyl]-propionic acid methyl ester

: 150933-22-5
2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid methyl ester

Guidance literature:: With 4,4'-diaminostilbene-2,2'-disulfonic acid;
DOI:10.1016/S0040-4039(00)60508-7

Reference yield:

: 81172-89-6
terephthalaldehyde mono(diethylacetal)

: 150933-22-5
2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1) NaH / 1) THF, 0 deg C, 2) 0 deg C

2: 50 percent / NaOMe / methanol / 1 h / 0 °C

3: 95 percent / H₂ / 10percent Pd/C / methanol

4: 93 percent / tetrahydrofuran

5: 1) oxalyl chloride, DMSO, 2) NEt₃ / CH₂Cl₂

6: 62 percent / DAST

With oxalyl dichloride; hydrogen; sodium methylate; sodium hydride; dimethyl sulfoxide; triethylamine; 4,4'-diaminostilbene-2,2'-disulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(00)60508-7

Reference yield:

: 150933-17-8
[(4-Formyl-phenyl)-hydroxy-methyl]-phosphonic acid diethyl ester

: 150933-22-5
2-tert-Butoxycarbonylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / NaOMe / methanol / 1 h / 0 °C

2: 95 percent / H₂ / 10percent Pd/C / methanol

3: 93 percent / tetrahydrofuran

4: 1) oxalyl chloride, DMSO, 2) NEt₃ / CH₂Cl₂

5: 62 percent / DAST

With oxalyl dichloride; hydrogen; sodium methylate; dimethyl sulfoxide; triethylamine; 4,4'-diaminostilbene-2,2'-disulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(00)60508-7