4-(3,4-dimethoxybenzyl)-5-(4-(diethylamino)benzyl)-1-methyl-1H-imidazol-2-amine

Base Information

Chemical Name:4-(3,4-dimethoxybenzyl)-5-(4-(diethylamino)benzyl)-1-methyl-1H-imidazol-2-amine
CAS No.:1620893-70-0
Molecular Formula:C₂₄H₃₂N₄O₂
Molecular Weight:408.544
Hs Code.:

Synonyms:4-(3,4-dimethoxybenzyl)-5-(4-(diethylamino)benzyl)-1-methyl-1H-imidazol-2-amine

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Chemical Property of 4-(3,4-dimethoxybenzyl)-5-(4-(diethylamino)benzyl)-1-methyl-1H-imidazol-2-amine

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Technology Process of 4-(3,4-dimethoxybenzyl)-5-(4-(diethylamino)benzyl)-1-methyl-1H-imidazol-2-amine

There total 7 articles about 4-(3,4-dimethoxybenzyl)-5-(4-(diethylamino)benzyl)-1-methyl-1H-imidazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1620893-68-6
4-((4-(3,4-bimethoxybenzyl)-2-azido-1-methyl-1H-imidazol-5-yl)methyl)-N,N-diethylbenzenamine

: 1620893-70-0
4-(3,4-dimethoxybenzyl)-5-(4-(diethylamino)benzyl)-1-methyl-1H-imidazol-2-amine

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 25 ℃; for 12h;
DOI:10.1016/j.ejmech.2014.06.016

Reference yield:

: 120-21-8
4-Diethylaminobenzaldehyde

: 1620893-70-0
4-(3,4-dimethoxybenzyl)-5-(4-(diethylamino)benzyl)-1-methyl-1H-imidazol-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethylmagnesium bromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

1.2: 24 h / 25 °C / Inert atmosphere

2.1: triethylsilane; boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / 0 - 60 °C / Inert atmosphere

3.1: ethylmagnesium bromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

3.2: 12 h / 25 °C / Inert atmosphere

4.1: tetrahydrofuran / 12 h / 25 °C / Inert atmosphere

5.1: acetic acid; hydrogen; palladium 10% on activated carbon / methanol / 24 h / 50 °C / 30402 Torr

6.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 - 25 °C

6.2: 1 h / -78 - 25 °C

7.1: sodium tetrahydroborate / methanol / 12 h / 0 - 25 °C

With triethylsilane; sodium tetrahydroborate; n-butyllithium; palladium 10% on activated carbon; boron trifluoride diethyl etherate; ethylmagnesium bromide; hydrogen; acetic acid; In tetrahydrofuran; methanol; hexane;
DOI:10.1016/j.ejmech.2014.06.016

Reference yield:

: 1620893-58-4
(4-(diethylamino)phenyl)(4-iodo-1-methyl-1H-imidazol-5-yl)methanol

: 1620893-70-0
4-(3,4-dimethoxybenzyl)-5-(4-(diethylamino)benzyl)-1-methyl-1H-imidazol-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylsilane; boron trifluoride diethyl etherate / tetrahydrofuran / 24 h / 0 - 60 °C / Inert atmosphere

2.1: ethylmagnesium bromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

2.2: 12 h / 25 °C / Inert atmosphere

3.1: tetrahydrofuran / 12 h / 25 °C / Inert atmosphere

4.1: acetic acid; hydrogen; palladium 10% on activated carbon / methanol / 24 h / 50 °C / 30402 Torr

5.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 - 25 °C

5.2: 1 h / -78 - 25 °C

6.1: sodium tetrahydroborate / methanol / 12 h / 0 - 25 °C

With triethylsilane; sodium tetrahydroborate; n-butyllithium; palladium 10% on activated carbon; boron trifluoride diethyl etherate; ethylmagnesium bromide; hydrogen; acetic acid; In tetrahydrofuran; methanol; hexane;
DOI:10.1016/j.ejmech.2014.06.016