2-chloro-4-pyrrolidin-1-ylbenzoyl chloride

Base Information

• Chemical Name: 2-chloro-4-pyrrolidin-1-ylbenzoyl chloride
• CAS No.: 911312-93-1
• Molecular Formula: C₁₁H₁₁Cl₂NO
• Molecular Weight: 244.12
• Mol file: 911312-93-1.mol

Synonyms:2-chloro-4-pyrrolidin-1-ylbenzoyl chloride

Chemical Property of 2-chloro-4-pyrrolidin-1-ylbenzoyl chloride

Chemical Property:

Purity/Quality:

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Technology Process of 2-chloro-4-pyrrolidin-1-ylbenzoyl chloride

There total 2 articles about 2-chloro-4-pyrrolidin-1-ylbenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-(pyrrolidin-1-yl)benzoic acid methyl ester (175153-38-5) → 2-chloro-4-pyrrolidin-1-ylbenzoyl chloride (911312-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / 5 N aq. NaOH / methanol / 15 h / Heating

2: SOCl₂; NMP / CH₂Cl₂ / 20 °C

With 1-methyl-pyrrolidin-2-one; sodium hydroxide; thionyl chloride; In methanol; dichloromethane;

DOI:10.1021/jm000108p

Reference yield:

methyl 2-chloro-4-fluorobenzoate (85953-29-3) → 2-chloro-4-pyrrolidin-1-ylbenzoyl chloride (911312-93-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / K₂CO₃ / 1-methyl-pyrrolidin-2-one / 5 h / 120 °C

2: 53 percent / 5 N aq. NaOH / methanol / 15 h / Heating

3: SOCl₂; NMP / CH₂Cl₂ / 20 °C

With 1-methyl-pyrrolidin-2-one; sodium hydroxide; thionyl chloride; potassium carbonate; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;

DOI:10.1021/jm000108p

Reference yield: 100.0%

(-)-trans-acetic acid 3-(3-acetyl-2-hydroxy-4,6-dimethoxyphenyl)-1-methyl-pyrrolidin-2-ylmethyl ester + 2-chloro-4-pyrrolidin-1-ylbenzoyl chloride (911312-93-1) → (+)-trans-2-chloro-4-pyrrolidin-1-yl-benzoic acid 2-(2-acetoxymethyl-1-methylpyrrolidin-3-yl)-6-acetyl-3,5-dimethoxy-phenyl ester

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

upstream raw materials:

methyl 2-chloro-4-fluorobenzoate

2-chloro-4-(pyrrolidin-1-yl)benzoic acid methyl ester

Downstream raw materials:

methyl [1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl] acetate

2-chloro-N-(2-formylphenyl)-4-pyrrolidin-1-ylbenzamide

[1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl] acetic acid

(5R)-[1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl]acetic acid