175153-38-5

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-Chloro-4-(1-pyrrolidinyl)benzoate is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new medicines. Its specific structural properties make it an important building block for creating a wide range of organic compounds with diverse applications in the medical field.
Used in Agrochemical Industry:
In the agrochemical industry, Methyl 2-Chloro-4-(1-pyrrolidinyl)benzoate is used as an intermediate in the production of pesticides. Its antibacterial and antifungal properties are harnessed to create effective solutions for controlling pests and diseases in agriculture, thereby contributing to increased crop yields and protection of plants.
Used in Organic Synthesis:
Methyl 2-Chloro-4-(1-pyrrolidinyl)benzoate is also used in organic synthesis across various industries. Its unique structure allows it to be a key component in the creation of complex organic compounds, which can be utilized in a multitude of applications, from chemical research to the development of new materials and products.

Upstream product

• 123-75-1 pyrrolidine 
• 85953-29-3 methyl 2-chloro-4-fluorobenzoate 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 872-50-4 1-methyl-pyrrolidin-2-one 

Downstream Products

• 911312-93-1 2-chloro-4-pyrrolidin-1-ylbenzoyl chloride 
• 192513-60-3 2-chloro-(4-pyrrolidin-1-yl) benzoic acid 

Relevant academic research and scientific papers

Mild, Metal-Free Oxidative Ring-Expansion Approach for the Synthesis of Benzo[ b]azepines

Benzo[b]azepines are important structural motifs for the pharmaceutical industry. However, their syntheses are usually lengthy, involving several steps, transition-metal catalysts, and/or harsh conditions. A novel, general, mild, and metal-free oxidative ring expansion tandem reaction of hydroquinolines with TMSCHN2 as a versatile soft nucleophile to gain access to these valuable compounds in a simple and straightforward manner is presented.

Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V2 receptor agonists

The present work describes the discovery of novel series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin (AVP) V2 receptor agonists. By replacing the amide juncture in YM-35278 with a direct ring connection gave compound 10a, which acts as a V2 receptor agonist. These studies provided the potent, orally active non-peptidic V2 receptor agonists 10a and 10j.

4,4-DIFLUORO-1,2,3,4-TETRAHYDRO-5H-1-BENZAZEPINE DERIVATIVES OR SALTS THEREOF

4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivatives, which have excellent arginine vasopressin V2 activity and are useful for a drug for the treatment of central diabetes insipidus and/or nocturia.

Benzoheterocyclic derivatives

A benzoheterocyclic derivative of the following formula [1]: and pharmaceutically acceptable salts thereof, which show excellent anti-vasopressin activity, vasopressin agonistic activity and oxytocin antagonistic activity, and are useful as a vasopressin antagonist, vasopressin agonist or oxytocin antagonist.

Novel design of nonpeptide AVP V2 receptor agonists: Structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine as a template

The discovery of a series of nonpeptide arginine vasopressin V2 receptor agonists is described. After identifying the aniline derivative 8 as our lead compound from the metabolites of compound 7 that showed antidiuretic activity by po administr