tert-butyl 2-[(4-cyano-2-fluorobenzyl)(methyl)amino]-3-methylbutanoate

Base Information

Chemical Name:tert-butyl 2-[(4-cyano-2-fluorobenzyl)(methyl)amino]-3-methylbutanoate
CAS No.:1355158-69-8
Molecular Formula:C₁₈H₂₅FN₂O₂
Molecular Weight:320.407
Hs Code.:

Synonyms:tert-butyl 2-[(4-cyano-2-fluorobenzyl)(methyl)amino]-3-methylbutanoate

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Chemical Property of tert-butyl 2-[(4-cyano-2-fluorobenzyl)(methyl)amino]-3-methylbutanoate

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Technology Process of tert-butyl 2-[(4-cyano-2-fluorobenzyl)(methyl)amino]-3-methylbutanoate

There total 3 articles about tert-butyl 2-[(4-cyano-2-fluorobenzyl)(methyl)amino]-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1355158-68-7
tert-butyl 2-[(4-cyano-2-fluorobenzyl) amino]-3-methylbutanoate

: 74-88-4
methyl iodide

: 1355158-69-8
tert-butyl 2-[(4-cyano-2-fluorobenzyl)(methyl)amino]-3-methylbutanoate

Guidance literature:: tert-butyl 2-[(4-cyano-2-fluorobenzyl) amino]-3-methylbutanoate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.333333h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 3h;

Reference yield:

: 6070-59-3
tert-butyl 2-amino-3-methylbutanoate

: 1355158-69-8
tert-butyl 2-[(4-cyano-2-fluorobenzyl)(methyl)amino]-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 - 20 °C

2.2: 3 h / 20 °C

With sodium hydride; sodium hydrogencarbonate; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 1355158-69-8
tert-butyl 2-[(4-cyano-2-fluorobenzyl)(methyl)amino]-3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: perchloric acid / 36 h / 20 °C

2.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 - 20 °C

3.2: 3 h / 20 °C

With perchloric acid; sodium hydride; sodium hydrogencarbonate; In N,N-dimethyl-formamide; mineral oil;