7-(N-trityl-3-azetidinyl)thio-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Base Information

Chemical Name:7-(N-trityl-3-azetidinyl)thio-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
CAS No.:124256-40-2
Molecular Formula:C₃₅H₂₈F₂N₂O₃S
Molecular Weight:594.682
Hs Code.:

Synonyms:7-(N-trityl-3-azetidinyl)thio-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

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Chemical Property of 7-(N-trityl-3-azetidinyl)thio-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

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Technology Process of 7-(N-trityl-3-azetidinyl)thio-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

There total 5 articles about 7-(N-trityl-3-azetidinyl)thio-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 124256-21-9
1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-mercapto-4-oxoquinoline-3-carboxylic acid

: 124256-78-6
N-trityl-3-azetidinyl methanesulfonate

: 124256-40-2
7-(N-trityl-3-azetidinyl)thio-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Guidance literature:: With triethylamine; In acetonitrile; for 6h; Heating;
DOI:10.1248/cpb.38.2190

Reference yield:

: 94242-51-0
1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester

: 124256-40-2
7-(N-trityl-3-azetidinyl)thio-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / 70percent NaSH / ethanol / 0.17 h / Heating

2: 89 percent / HOAc, H₂SO₄, H₂O / 1 h / Heating

3: 83 percent / NEt₃ / acetonitrile / 6 h / Heating

With sodium hydrogensulfide; sulfuric acid; water; acetic acid; triethylamine; In ethanol; acetonitrile;
DOI:10.1248/cpb.38.2190

Reference yield:

: 76-83-5
trityl chloride

: 124256-40-2
7-(N-trityl-3-azetidinyl)thio-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: NEt₃ / CHCl₃ / 1 h / ice-cooling

2: NEt₃ / toluene / 1 h / Ambient temperature

3: 83 percent / NEt₃ / acetonitrile / 6 h / Heating

With triethylamine; In chloroform; toluene; acetonitrile;
DOI:10.1248/cpb.38.2190