1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester

Base Information

• Chemical Name: 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester
• CAS No.: 94242-51-0
• Molecular Formula: C15H12F3NO3
• Molecular Weight: 311.26
• European Community (EC) Number: 619-003-9
• DSSTox Substance ID: DTXSID10336680
• Nikkaji Number: J920.543H
• Wikidata: Q82103965
• ChEMBL ID: CHEMBL1543360
• Mol file: 94242-51-0.mol

Synonyms:94242-51-0;1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester;BAS 00805195;1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid ethyl ester;ethyl 1-cyclopropyl-6,7,8-trifluoro-4-oxoquinoline-3-carboxylate;Ethyl 1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate;TimTec1_008129;Oprea1_041958;Oprea1_070329;MLS000765987;SCHEMBL2844967;CHEMBL1543360;DTXSID10336680;HMS1557B11;HMS2678B08;AMY40733;AKOS000637019;SMR000279693;CS-0164478;FT-0665408;F19227;SR-01000311340;SR-01000311340-1;1-Cyclopropyl-4-oxo-6,7,8-trifluoro-1,4-dihydroquinoline-3-carboxylic acid ethyl ester;1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, ethyl ester;1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylicAcidEthylEster;1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester;1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, ethyl ester;ethyl 1-cyclopropyl-1,4-dihydro-4-oxo-6,7,8-trifluoroquinoline-3-carboxylate;ethyl 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylate;ethyl 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate;ethyl 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate;Ethyl 1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate #;ethyl 1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylate;1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester? (Moxifloxacin Impurity pound(c)

Chemical Property of 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester

Chemical Property:

• Melting Point: 167-168 °C
• Boiling Point: 417.7±45.0 °C(Predicted)
• PKA: -4.07±0.40(Predicted)
• PSA: 48.30000
• Density: 1.491±0.06 g/cm3(Predicted)
• LogP: 2.93040
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Methanol (Sparingly)
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 311.07692773
• Heavy Atom Count: 22
• Complexity: 520

Purity/Quality:

97% ^*data from raw suppliers

1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CN(C2=C(C(=C(C=C2C1=O)F)F)F)C3CC3
• Uses: Intermediate in the preparation of Moxifloxacin derivatives.

Technology Process of 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester

There total 15 articles about 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester (94242-51-0)

Guidance literature:

Reference yield: 91.0%

N,N-dimethylaminoacrylic acid ethyl ester (16173-58-3) + 2,3,4,5-tetrafluorobenzoyl chloride (94695-48-4) + Cyclopropylamine (765-30-0) → 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester (94242-51-0)

Guidance literature:

With potassium carbonate; acetic acid; triethylamine; In water; isopropyl alcohol; toluene;

Reference yield: 86.5%

ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate (94695-50-8) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + Cyclopropylamine (765-30-0) → 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester (94242-51-0)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; N-methyl-acetamide; ethanol; water;

upstream raw materials:

α-<(cyclopropylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate

orthoformic acid triethyl ester

Cyclopropylamine

Downstream raw materials:

1-cyclopropyl-6,7,8-trifluoro-1,2,3,4-tetrahydro-2-phenyl-4-oxo-3-quinolinecarboxylic acid ethyl ester

1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinolin-3-carboxylic acid

1-Cyclopropyl-6,8-difluoro-7-((R)-3-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

1-Cyclopropyl-6,8-difluoro-7-((S)-3-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 94242-51-0 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send