4-(4-chloro-phenyl)-5-[5-chloro-2-(2H-tetrazol-5-ylmethoxy)-phenyl]-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

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Chemical Name:4-(4-chloro-phenyl)-5-[5-chloro-2-(2H-tetrazol-5-ylmethoxy)-phenyl]-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one
CAS No.:1441755-52-7
Molecular Formula:C₂₉H₂₅Cl₂N₇O₃
Molecular Weight:590.469
Hs Code.:

Synonyms:4-(4-chloro-phenyl)-5-[5-chloro-2-(2H-tetrazol-5-ylmethoxy)-phenyl]-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

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Chemical Property of 4-(4-chloro-phenyl)-5-[5-chloro-2-(2H-tetrazol-5-ylmethoxy)-phenyl]-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

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Technology Process of 4-(4-chloro-phenyl)-5-[5-chloro-2-(2H-tetrazol-5-ylmethoxy)-phenyl]-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

There total 14 articles about 4-(4-chloro-phenyl)-5-[5-chloro-2-(2H-tetrazol-5-ylmethoxy)-phenyl]-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1441755-60-7
{4-chloro-2-[4-(4-chloro-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-6-oxo-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazol-5-yl]-phenoxy}-acetonitrile

: 1441755-52-7
4-(4-chloro-phenyl)-5-[5-chloro-2-(2H-tetrazol-5-ylmethoxy)-phenyl]-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 100 ℃; for 7h; Inert atmosphere;

Reference yield:

: 1441739-64-5
5-isopropyl-1-(2-methoxy-phenyl)-4-vinyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1441755-52-7
4-(4-chloro-phenyl)-5-[5-chloro-2-(2H-tetrazol-5-ylmethoxy)-phenyl]-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide; sodium periodate / 1,4-dioxane; water; tert-butyl alcohol / 2 h / 20 °C

2.1: tetrahydrofuran; diethyl ether / 0.17 h / -10 °C / Inert atmosphere

3.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C

4.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 20 h / 20 °C

5.1: HATU; 4-methyl-morpholine / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere

6.1: ammonium chloride; sodium azide / N,N-dimethyl-formamide / 7 h / 100 °C / Inert atmosphere

With 4-methyl-morpholine; sodium periodate; osmium(VIII) oxide; sodium azide; lithium hydroxide monohydrate; ammonium chloride; 4-methylmorpholine N-oxide; triethylamine; HATU; Methanesulfonic anhydride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1441739-72-5
4-formyl-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

: 1441755-52-7
4-(4-chloro-phenyl)-5-[5-chloro-2-(2H-tetrazol-5-ylmethoxy)-phenyl]-3-isopropyl-2-(2-methoxy-phenyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyrazol-6-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran; diethyl ether / 0.17 h / -10 °C / Inert atmosphere

2.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C

3.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 20 h / 20 °C

4.1: HATU; 4-methyl-morpholine / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere

5.1: ammonium chloride; sodium azide / N,N-dimethyl-formamide / 7 h / 100 °C / Inert atmosphere

With 4-methyl-morpholine; sodium azide; lithium hydroxide monohydrate; ammonium chloride; triethylamine; HATU; Methanesulfonic anhydride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;