{4-chloro-2-[4-(4-chloro-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-6-oxo-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazol-5-yl]-phenoxy}-acetonitrile

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Chemical Name:{4-chloro-2-[4-(4-chloro-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-6-oxo-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazol-5-yl]-phenoxy}-acetonitrile
CAS No.:1441755-60-7
Molecular Formula:C₂₉H₂₄Cl₂N₄O₃
Molecular Weight:547.441
Hs Code.:

Synonyms:{4-chloro-2-[4-(4-chloro-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-6-oxo-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazol-5-yl]-phenoxy}-acetonitrile

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Chemical Property of {4-chloro-2-[4-(4-chloro-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-6-oxo-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazol-5-yl]-phenoxy}-acetonitrile

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Technology Process of {4-chloro-2-[4-(4-chloro-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-6-oxo-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazol-5-yl]-phenoxy}-acetonitrile

There total 13 articles about {4-chloro-2-[4-(4-chloro-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-6-oxo-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazol-5-yl]-phenoxy}-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1441755-68-5
4-[(5-chloro-2-cyanomethoxy-phenylamino)-(4-chloro-phenyl)-methyl]-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid

: 1441755-60-7
{4-chloro-2-[4-(4-chloro-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-6-oxo-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazol-5-yl]-phenoxy}-acetonitrile

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 80 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1441739-64-5
5-isopropyl-1-(2-methoxy-phenyl)-4-vinyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1441755-60-7
{4-chloro-2-[4-(4-chloro-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-6-oxo-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazol-5-yl]-phenoxy}-acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide; sodium periodate / 1,4-dioxane; water; tert-butyl alcohol / 2 h / 20 °C

2.1: tetrahydrofuran; diethyl ether / 0.17 h / -10 °C / Inert atmosphere

3.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C

4.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 20 h / 20 °C

5.1: HATU; 4-methyl-morpholine / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere

With 4-methyl-morpholine; sodium periodate; osmium(VIII) oxide; lithium hydroxide monohydrate; 4-methylmorpholine N-oxide; triethylamine; HATU; Methanesulfonic anhydride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1441739-72-5
4-formyl-5-isopropyl-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

: 1441755-60-7
{4-chloro-2-[4-(4-chloro-phenyl)-3-isopropyl-2-(2-methoxy-phenyl)-6-oxo-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazol-5-yl]-phenoxy}-acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; diethyl ether / 0.17 h / -10 °C / Inert atmosphere

2.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C

3.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 20 h / 20 °C

4.1: HATU; 4-methyl-morpholine / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere

With 4-methyl-morpholine; lithium hydroxide monohydrate; triethylamine; HATU; Methanesulfonic anhydride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;