2-methyl-4-(2-(N-1-oxy-2-chloroethyl)amino-4-methoxy)anilinoquinazoline

Base Information

Chemical Name:2-methyl-4-(2-(N-1-oxy-2-chloroethyl)amino-4-methoxy)anilinoquinazoline
CAS No.:1494589-76-2
Molecular Formula:C₁₈H₁₇ClN₄O₂
Molecular Weight:356.812
Hs Code.:

Synonyms:2-methyl-4-(2-(N-1-oxy-2-chloroethyl)amino-4-methoxy)anilinoquinazoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-4-(2-(N-1-oxy-2-chloroethyl)amino-4-methoxy)anilinoquinazoline

Chemical Property:

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Technology Process of 2-methyl-4-(2-(N-1-oxy-2-chloroethyl)amino-4-methoxy)anilinoquinazoline

There total 4 articles about 2-methyl-4-(2-(N-1-oxy-2-chloroethyl)amino-4-methoxy)anilinoquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1494589-74-0
4-(2-amino-4-methoxyphenyl)amino-2-methylquinazoline

: 79-04-9
chloroacetyl chloride

: 1494589-76-2
2-methyl-4-(2-(N-1-oxy-2-chloroethyl)amino-4-methoxy)anilinoquinazoline

Guidance literature:: With potassium carbonate; In acetone; at 0 ℃; for 1h;
DOI:10.1021/jm4016526

Reference yield:

: 1494589-70-6
2-methyl-4-(2-nitro-4-methoxyphenyl)aminoquinazoline

: 1494589-76-2
2-methyl-4-(2-(N-1-oxy-2-chloroethyl)amino-4-methoxy)anilinoquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C

2: potassium carbonate / acetone / 1 h / 0 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethyl acetate; acetone;
DOI:10.1021/jm4016526

Reference yield:

: 96-96-8
4-methoxy-2-nitroaniline

: 1494589-76-2
2-methyl-4-(2-(N-1-oxy-2-chloroethyl)amino-4-methoxy)anilinoquinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / isopropyl alcohol; water / 5 h / Reflux

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C

3: potassium carbonate / acetone / 1 h / 0 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; In water; ethyl acetate; isopropyl alcohol; acetone;
DOI:10.1021/jm4016526