Technology Process of ethyl (4R,7R,E)-7-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyloxy)oct-2-enoate
There total 7 articles about ethyl (4R,7R,E)-7-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyloxy)oct-2-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / 0 - 20 °C
2.1: diisobutylaluminium hydride / dichloromethane / 0.5 h / -78 °C
2.2: 0.5 h / Saturated solution
3.1: L-proline / dimethyl sulfoxide / 20 °C / Inert atmosphere
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / dimethyl sulfoxide; acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere
5.1: copper(ll) sulfate pentahydrate / methanol / 20 °C
6.1: toluene-4-sulfonic acid / dichloromethane / 8 h / 0 - 20 °C
With
sodium tetrahydroborate; copper(ll) sulfate pentahydrate; nickel(II) chloride hexahydrate; diisobutylaluminium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; L-proline; lithium chloride;
In
methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
4.1: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.tetasy.2012.01.014
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / dimethyl sulfoxide; acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere
2: copper(ll) sulfate pentahydrate / methanol / 20 °C
3: toluene-4-sulfonic acid / dichloromethane / 8 h / 0 - 20 °C
With
copper(ll) sulfate pentahydrate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride;
In
methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
1: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.tetasy.2012.01.014
- Guidance literature:
-
Multi-step reaction with 2 steps
1: copper(ll) sulfate pentahydrate / methanol / 20 °C
2: toluene-4-sulfonic acid / dichloromethane / 8 h / 0 - 20 °C
With
copper(ll) sulfate pentahydrate; toluene-4-sulfonic acid;
In
methanol; dichloromethane;
DOI:10.1016/j.tetasy.2012.01.014
