N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}acetamide

Base Information

• Chemical Name: N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}acetamide
• CAS No.: 1448991-05-6
• Molecular Formula: C₂₀H₂₄N₂O
• Molecular Weight: 308.423
• Mol file: 1448991-05-6.mol

Synonyms:N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}acetamide

Chemical Property of N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}acetamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}acetamide

There total 4 articles about N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methanamine (1448991-03-4) + acetyl chloride (75-36-5) → N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}acetamide (1448991-05-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 48h; Inert atmosphere;

DOI:10.3987/COM-12-S(N)82

Reference yield:

(2R,3R)-1-benzyl-3-chloro-2-phenylpiperidine (1448990-99-5) → N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}acetamide (1448991-05-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide / dimethyl sulfoxide; N,N-dimethyl-formamide / 2 h / 55 °C / Microwave irradiation

2: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 3102.97 Torr

3: triethylamine / tetrahydrofuran / 48 h / 0 - 20 °C / Inert atmosphere

With sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.3987/COM-12-S(N)82

Reference yield:

(S)-2-[(S)-azido(phenyl)methyl]-1-benzylpyrrolidine (1448991-00-1) → N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}acetamide (1448991-05-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 3102.97 Torr

2: triethylamine / tetrahydrofuran / 48 h / 0 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; ethanol;

DOI:10.3987/COM-12-S(N)82

upstream raw materials:

(S)-1-[(2S)-1-benzylpyrrolidin-2-yl](phenyl)methanol

(2R,3R)-1-benzyl-3-chloro-2-phenylpiperidine

(S)-2-[(S)-azido(phenyl)methyl]-1-benzylpyrrolidine

(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methanamine