(2R,4S,5R,6R)-5-Acetylamino-6-[(1R,2R)-1,2-dihydroxy-3-(toluene-4-sulfonyloxy)-propyl]-4-hydroxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2R,4S,5R,6R)-5-Acetylamino-6-[(1R,2R)-1,2-dihydroxy-3-(toluene-4-sulfonyloxy)-propyl]-4-hydroxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester
CAS No.:173911-65-4
Molecular Formula:C₂₄H₃₉NO₁₁SSi
Molecular Weight:577.725
Hs Code.:

(2R,4S,5R,6R)-5-Acetylamino-6-[(1R,2R)-1,2-dihydroxy-3-(toluene-4-sulfonyloxy)-propyl]-4-hydroxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Synonyms:(2R,4S,5R,6R)-5-Acetylamino-6-[(1R,2R)-1,2-dihydroxy-3-(toluene-4-sulfonyloxy)-propyl]-4-hydroxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

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Chemical Property of (2R,4S,5R,6R)-5-Acetylamino-6-[(1R,2R)-1,2-dihydroxy-3-(toluene-4-sulfonyloxy)-propyl]-4-hydroxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

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Technology Process of (2R,4S,5R,6R)-5-Acetylamino-6-[(1R,2R)-1,2-dihydroxy-3-(toluene-4-sulfonyloxy)-propyl]-4-hydroxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

There total 1 articles about (2R,4S,5R,6R)-5-Acetylamino-6-[(1R,2R)-1,2-dihydroxy-3-(toluene-4-sulfonyloxy)-propyl]-4-hydroxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 122777-22-4
methyl <2-(trimethylsilyl)ethyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosid>onate

: 98-59-9
p-toluenesulfonyl chloride

: 173911-65-4
(2R,4S,5R,6R)-5-Acetylamino-6-[(1R,2R)-1,2-dihydroxy-3-(toluene-4-sulfonyloxy)-propyl]-4-hydroxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Guidance literature:: With pyridine; In dichloromethane; at -80 ℃; for 48h;
DOI:10.1021/jo950994p

Reference yield:

: 173911-65-4
(2R,4S,5R,6R)-5-Acetylamino-6-[(1R,2R)-1,2-dihydroxy-3-(toluene-4-sulfonyloxy)-propyl]-4-hydroxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

: 173911-74-5
C₃₄H₅₃N₃O₁₅SSi

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / NaN₃, 18-crown-6 / dimethylformamide / 20 h / 60 °C

2: 95 percent / Et₃N / CH₂Cl₂ / 18 h / -30 °C

3: 23 percent / CF₃SO₃Ag, MeSBr / acetonitrile / 2 h / -40 °C

4: 80 percent / NaOMe / methanol; toluene / 16 h / Ambient temperature

5: 87 percent / Ph₃P / tetrahydrofuran; H₂O / 20 h / 40 °C

With sodium azide; 18-crown-6 ether; methanesulfonyl bromide; sodium methylate; silver trifluoromethanesulfonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jo950994p

Reference yield:

: 173911-65-4
(2R,4S,5R,6R)-5-Acetylamino-6-[(1R,2R)-1,2-dihydroxy-3-(toluene-4-sulfonyloxy)-propyl]-4-hydroxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

: 173911-73-4
methyl (2-(trimethylsilyl)ethyl 5-acetamido-9-azido-3,5,9-trideoxy-8-O-{methyl [5-acetamido-3,5-dideoxy-3-(phenylthio)-D-erythro-α-L-gluco-2-nonulopyranosid]onate}-D-glycero-α-D-galacto-2-nonulopyranosid)onate

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / NaN₃, 18-crown-6 / dimethylformamide / 20 h / 60 °C

2: 95 percent / Et₃N / CH₂Cl₂ / 18 h / -30 °C

3: 23 percent / CF₃SO₃Ag, MeSBr / acetonitrile / 2 h / -40 °C

4: 80 percent / NaOMe / methanol; toluene / 16 h / Ambient temperature

With sodium azide; 18-crown-6 ether; methanesulfonyl bromide; sodium methylate; silver trifluoromethanesulfonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jo950994p