(2R,4S,5R,6R)-5-Acetylamino-6-((1R,2R)-3-azido-1,2-dihydroxy-propyl)-4-benzoyloxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2R,4S,5R,6R)-5-Acetylamino-6-((1R,2R)-3-azido-1,2-dihydroxy-propyl)-4-benzoyloxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester
CAS No.:173911-67-6
Molecular Formula:C₂₄H₃₆N₄O₉Si
Molecular Weight:552.657
Hs Code.:

(2R,4S,5R,6R)-5-Acetylamino-6-((1R,2R)-3-azido-1,2-dihydroxy-propyl)-4-benzoyloxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Synonyms:(2R,4S,5R,6R)-5-Acetylamino-6-((1R,2R)-3-azido-1,2-dihydroxy-propyl)-4-benzoyloxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

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Chemical Property of (2R,4S,5R,6R)-5-Acetylamino-6-((1R,2R)-3-azido-1,2-dihydroxy-propyl)-4-benzoyloxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

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Technology Process of (2R,4S,5R,6R)-5-Acetylamino-6-((1R,2R)-3-azido-1,2-dihydroxy-propyl)-4-benzoyloxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

There total 6 articles about (2R,4S,5R,6R)-5-Acetylamino-6-((1R,2R)-3-azido-1,2-dihydroxy-propyl)-4-benzoyloxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 98-88-4
benzoyl chloride

: 173911-66-5
(2R,4S,5R,6R)-5-Acetylamino-6-((1R,2R)-3-azido-1,2-dihydroxy-propyl)-4-hydroxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

: 173911-67-6
(2R,4S,5R,6R)-5-Acetylamino-6-((1R,2R)-3-azido-1,2-dihydroxy-propyl)-4-benzoyloxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

: (2R,4S,5R,6R)-5-Acetylamino-6-((1R,2R)-3-azido-2-benzoyloxy-1-hydroxy-propyl)-4-benzoyloxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Guidance literature:: With pyridine; In dichloromethane; at -80 ℃; for 96h;
DOI:10.1021/jo950994p

Reference yield:

: 122777-22-4
methyl <2-(trimethylsilyl)ethyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosid>onate

: 173911-67-6
(2R,4S,5R,6R)-5-Acetylamino-6-((1R,2R)-3-azido-1,2-dihydroxy-propyl)-4-benzoyloxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / pyridine / CH₂Cl₂ / 48 h / -80 °C

2: 83 percent / NaN₃, 18-crown-6 / dimethylformamide / 20 h / 60 °C

3: 95 percent / Et₃N / CH₂Cl₂ / 18 h / -30 °C

With pyridine; sodium azide; 18-crown-6 ether; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo950994p

Reference yield:

: 122777-27-9
Methyl [2-(trimethylsilyl)ethyl 5-acetamido-4,7-di-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosid]onate

: 173911-67-6
(2R,4S,5R,6R)-5-Acetylamino-6-((1R,2R)-3-azido-1,2-dihydroxy-propyl)-4-benzoyloxy-2-(2-trimethylsilanyl-ethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / pyridine / 1.) 0 deg C, 5 h, 2.) room temperature, 17 h

2: 82 percent / LiN₃, 15-crown-5 / tetrahydrofuran / 24 h / 45 °C

3: 89 percent / NaOMe / methanol / 2 h / Ambient temperature

4: 95 percent / Et₃N / CH₂Cl₂ / 18 h / -30 °C

With pyridine; lithium azide; 15-crown-5; sodium methylate; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo950994p