Triisopropyl-[(S)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-cyclohex-1-enyloxy]-silane

Base Information

Chemical Name:Triisopropyl-[(S)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-cyclohex-1-enyloxy]-silane
CAS No.:208193-00-4
Molecular Formula:C₂₃H₃₆O₄Si
Molecular Weight:404.622
Hs Code.:

Synonyms:Triisopropyl-[(S)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-cyclohex-1-enyloxy]-silane

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Chemical Property of Triisopropyl-[(S)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-cyclohex-1-enyloxy]-silane

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Technology Process of Triisopropyl-[(S)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-cyclohex-1-enyloxy]-silane

There total 9 articles about Triisopropyl-[(S)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-cyclohex-1-enyloxy]-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 208192-99-8
4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-cyclohexanone

: Triisopropyl-[(R)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-cyclohex-1-enyloxy]-silane

: 208193-00-4
Triisopropyl-[(S)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-cyclohex-1-enyloxy]-silane

Guidance literature:: With (+)-bis(α-methylbenzyl)amine lithium salt; lithium chloride; In tetrahydrofuran; at -78 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/ja980407s

Reference yield:

: 91511-83-0
5-bromo-7-methoxy-1,3-benzodioxol

: 208193-00-4
Triisopropyl-[(S)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-cyclohex-1-enyloxy]-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THf, hexane, -78 deg C, 3 h, 2.) THF, hexane, -78 deg C to rt, 2 h

2: 97 percent / POCl₃, DBU / pyridine / 20 - 80 °C

3: 87 percent / H₂ / Pd/C / methanol / 1.5 h

4: 89 percent / H₂SO₄ / dioxane; H₂O / 0.67 h / Ambient temperature

5: n-BuLi, LiCl, (+)-bis(α-methoxybenzyl)amine / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; (+)-bis(α-methoxybenzyl)amine; sulfuric acid; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; hexane; water;
DOI:10.1016/S0040-4020(98)00975-2

Reference yield:

: 208193-14-0
6-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-4-methoxy-benzo[1,3]dioxole

: 208193-00-4
Triisopropyl-[(S)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-cyclohex-1-enyloxy]-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / H₂ / Pd/C / methanol / 1.5 h

2: 89 percent / H₂SO₄ / dioxane; H₂O / 0.67 h / Ambient temperature

3: n-BuLi, LiCl, (+)-bis(α-methoxybenzyl)amine / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; (+)-bis(α-methoxybenzyl)amine; sulfuric acid; hydrogen; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water;
DOI:10.1016/S0040-4020(98)00975-2