6-Bromo-4-methoxy-1,3-benzodioxole

Base Information

• Chemical Name: 6-Bromo-4-methoxy-1,3-benzodioxole
• CAS No.: 91511-83-0
• Molecular Formula: C8H7 Br O3
• Molecular Weight: 231.046
• Nikkaji Number: J1.999.500C
• Mol file: 91511-83-0.mol

Synonyms:6-Bromo-4-methoxy-1,3-benzodioxole;91511-83-0;1,3-Benzodioxole, 6-bromo-4-methoxy-;6-Bromo-4-methoxybenzo[d][1,3]dioxole;SCHEMBL5387246;PQIWDZBUHXVOKA-UHFFFAOYSA-N;6-bromo-4-methoxy-1,3-dioxaindane;AC7237;MFCD22555991;AKOS024100328;SY030601;bromo-3,4-methylenedioxy-5-methoxybenzene;1bromo-3,4-methylenedioxy-5-methoxybenzene;1-bromo-3,4-methylenedioxy-5-methoxvbenzene;1-bromo-3,4-methylenedioxy-5-methoxybenzene;1 -bromo-3,4-methylenedioxy-5-methoxybenzene;EN300-7924270;A916777;Z1551954982

Chemical Property of 6-Bromo-4-methoxy-1,3-benzodioxole

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 229.95786
• Heavy Atom Count: 12
• Complexity: 164

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-4-methoxy-1,3-benzodioxole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=CC2=C1OCO2)Br

Technology Process of 6-Bromo-4-methoxy-1,3-benzodioxole

There total 5 articles about 6-Bromo-4-methoxy-1,3-benzodioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

chlorobromomethane (74-97-5) + 5-bromo-3-methoxybenzene-1,2-diol (38790-07-7) → 5-bromo-7-methoxy-1,3-benzodioxol (91511-83-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

DOI:10.1016/S0040-4020(98)00975-2

Reference yield: 77.0%

diiodomethane (75-11-6) + 5-bromo-3-methoxybenzene-1,2-diol (38790-07-7) → 5-bromo-7-methoxy-1,3-benzodioxol (91511-83-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0036-1588515

Reference yield: 71.0%

5-bromo-3-methoxybenzene-1,2-diol (38790-07-7) + 1,1-dibromomethane (74-95-3) → 5-bromo-7-methoxy-1,3-benzodioxol (91511-83-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1.5h;

upstream raw materials:

5-bromo-3-methoxybenzene-1,2-diol

1,1-dibromomethane

chlorobromomethane

5-bromo-3-methoxysalicylaldehyde

Downstream raw materials:

2-(3-methoxy-4,5-methylenedioxyphenyl)ethanol

((1R,2S,3S)-1-(2-bromo-3,4,5-trimethoxyphenyl)-4-(5-bromo-4-methoxybenzo[d][1,3]dioxol-6-yl)-2,3-dimethylbutoxy)(tert-butyl)dimethylsilane

gomisin O

[(1R,2S,3S,4S,5R,6R)-2,3,4,5-Tetrahydroxy-6-(7-methoxy-benzo[1,3]dioxol-5-yl)-cyclohexyl]-carbamic acid methyl ester