(S)-1-(4-methoxyphenyl)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-ol

Base Information

• Chemical Name: (S)-1-(4-methoxyphenyl)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-ol
• CAS No.: 1220326-96-4
• Molecular Formula: C₁₉H₂₈O₄
• Molecular Weight: 320.429
• Mol file: 1220326-96-4.mol

Synonyms:(S)-1-(4-methoxyphenyl)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-ol

Chemical Property of (S)-1-(4-methoxyphenyl)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(4-methoxyphenyl)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-ol

There total 5 articles about (S)-1-(4-methoxyphenyl)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) + C12H20O3 → (S)-1-(4-methoxyphenyl)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-ol (1220326-96-4)

Guidance literature:

1-bromo-4-methoxy-benzene; With magnesium; In tetrahydrofuran; at 20 ℃;

C₁₂H₂₀O₃; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

DOI:10.1016/j.tetasy.2010.01.002

Reference yield:

(S)-1-(4-methoxyphenyl)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-one (1451998-74-5) → (S)-1-(4-methoxyphenyl)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-ol (1220326-96-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 1h;

DOI:10.1002/ejoc.201300097

Reference yield:

(4-methoxy-phenyl)-morpholin-4-yl-acetonitrile (15190-13-3) → (S)-1-(4-methoxyphenyl)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-ol (1220326-96-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: copper(ll) sulfate pentahydrate; water / methanol / 1.5 h / 60 °C

3.1: sodium tetrahydroborate / methanol / 1 h

With sodium tetrahydroborate; copper(ll) sulfate pentahydrate; water; sodium hydride; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201300097

upstream raw materials:

1-bromo-4-methoxy-benzene

(S)-1-(4-methoxyphenyl)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-one

(4S)-1-bromo-4,5-cyclohexylidenedioxypentane

(4-methoxy-phenyl)-morpholin-4-yl-acetonitrile

Downstream raw materials:

((2S,6R)-6-(4-methoxyphenyl) tetrahydro-2H-pyran-2-yl) methanol

1-(3,4-dimethoxyphenyl)-2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethanone

1-(4-methoxyphenyl)-2-((2S,6R)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)ethanone

(2S,6R)-2-(3,4-dimethoxyphenethyl)-6-(4-methoxyphenyl)tetrahydro-2H-pyran