(R)-tert-butyl 3-(3-(3-bromo-1-trityl-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 3-(3-(3-bromo-1-trityl-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate
• CAS No.: 1374353-11-3
• Molecular Formula: C₃₈H₃₇BrN₆O₂
• Molecular Weight: 689.655
• Mol file: 1374353-11-3.mol

Synonyms:(R)-tert-butyl 3-(3-(3-bromo-1-trityl-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate

Chemical Property of (R)-tert-butyl 3-(3-(3-bromo-1-trityl-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 3-(3-(3-bromo-1-trityl-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate

There total 5 articles about (R)-tert-butyl 3-(3-(3-bromo-1-trityl-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-tert-butyl 3-(3-(3-bromo-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate (1374353-10-2) + trityl chloride (76-83-5) → (R)-tert-butyl 3-(3-(3-bromo-1-trityl-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate (1374353-11-3) + C57H51BrN6O2 (1374353-12-4)

Guidance literature:

(R)-tert-butyl 3-(3-(3-bromo-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

trityl chloride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

(3R)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (194726-40-4) → (R)-tert-butyl 3-(3-(3-bromo-1-trityl-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate (1374353-11-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrazine / methanol / 3 h / 100 °C / Microwave irradiation

2.1: methanol / 85 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 0 - 20 °C

With sodium hydride; hydrazine; In methanol; N,N-dimethyl-formamide;

Reference yield:

3-bromo-1H-indazole-5-carbonitrile (395101-67-4) → (R)-tert-butyl 3-(3-(3-bromo-1-trityl-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate (1374353-11-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / 0 - 20 °C

2.1: methanol / 85 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 0 - 20 °C

With hydrogenchloride; sodium hydride; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

(R)-tert-butyl 3-(3-(3-bromo-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate

trityl chloride

(3R)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

3-bromo-1H-indazole-5-carbonitrile

Downstream raw materials:

(R)-tert-butyl 3-(3-(3-(pyridin-4-yl)-1-trityl-1H-indazol-5-yl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate

(R)-5-(5-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole