(1R,6S,8aR)-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione

Base Information

Chemical Name:(1R,6S,8aR)-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione
CAS No.:1050393-84-4
Molecular Formula:C₁₄H₁₂F₃NO₃
Molecular Weight:299.249
Hs Code.:

Synonyms:(1R,6S,8aR)-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,6S,8aR)-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione

Chemical Property:

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Technology Process of (1R,6S,8aR)-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione

There total 12 articles about (1R,6S,8aR)-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68766-96-1
ethyl (R)-2-pyrrolidone-5-carboxylate

: 1004791-36-9
(1S,6S,8aR)-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione

: 1050393-84-4
(1R,6S,8aR)-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine / dmap / tetrahydrofuran / 5 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: tetrahydrofuran / 1 h / -40 °C

3.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

5.1: triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

5.2: 0.33 h / 20 °C

6.1: lithium borohydride / tetrahydrofuran / 13.5 h / 0 - 20 °C

7.1: oxalyl dichloride; dimethyl sulfoxide / tetrahydrofuran / 0.75 h / -78 °C

7.2: 1 h / -78 - 20 °C

8.1: tetrahydrofuran / 1 h / -78 °C

9.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

10.1: 4 h / 120 °C

With hydrogenchloride; lithium borohydride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; dmap; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: (R)-1-[(S)-5-(3,4,5-trifluorophenyl)pyrrolidine-2-yl]ethanol

: 95-92-1
oxalic acid diethyl ester

: 1004791-36-9
(1S,6S,8aR)-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione

: 1050393-84-4
(1R,6S,8aR)-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione

Guidance literature:: at 120 ℃; for 4h;

Reference yield:

: 937400-23-2
(R)-2-tert-butoxycarbonylamino-5-oxo-5-(3,4,5-trifluorophenyl)pentanoic acid ethyl ester

: 1004791-36-9
(1S,6S,8aR)-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione

: 1050393-84-4
(1R,6S,8aR)-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

3.2: 0.33 h / 20 °C

4.1: lithium borohydride / tetrahydrofuran / 13.5 h / 0 - 20 °C

5.1: oxalyl dichloride; dimethyl sulfoxide / tetrahydrofuran / 0.75 h / -78 °C

5.2: 1 h / -78 - 20 °C

6.1: tetrahydrofuran / 1 h / -78 °C

7.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

8.1: 4 h / 120 °C

With hydrogenchloride; lithium borohydride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;