937400-23-2

Upstream product

• 144978-12-1 1-tert-butyl 2-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate 
• 156006-28-9 3,4,5-trifluorophenylmagnesium bromide 
• 68766-96-1 ethyl (R)-2-pyrrolidone-5-carboxylate 
• 138526-69-9 3,4,5-trifluoro-1-bromobenzene 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1050393-51-5 (R)-5-(3,4,5-trifluorophenyl)-3,4-dihydro-2H-pyrrole-2-carboxylic acid ethyl ester 
• 1050394-83-6 (6S,8aR)-3-[3-methoxy-4-(4-methylimidazol-1-yl)benzylidene]-1,1-cyclopropyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazin-4-one 
• 1004791-37-0 (Z)-(1S,6S,8aR)-3-[3-methoxy-4-(4-methyl-1H-imidazole-1-yl)benzylidene]-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrole[2,1-c][1,4]oxazine-4-one 
• 1050394-79-0 (6S,8aR)-1,1-cyclopropyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione 
• 1004791-36-9 (1S,6S,8aR)-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione 
• 1050393-84-4 (1R,6S,8aR)-1-methyl-6-(3,4,5-trifluorophenyl)tetrahydropyrrolo[2,1-c][1,4]oxazine-3,4-dione 
• 1050394-71-2 1-[(2R,5S)-1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-yl]cyclopropanol 
• 1004791-32-5 (2R,5S)-5-(3,4,5-trifluorophenyl)-pyrrolidine-1,2-dicarboxylic acid 1-t-butyl ester 2-ethyl ester 
• 1050394-66-5 (2R,5S)-1-benzyl-5-(3,4,5-trifluorophenyl)pyrrolidine-2-carboxylic acid ethyl ester 
• 1050394-75-6 1-[(2R,5S)-5-(3,4,5-trifluorophenyl)pyrrolidine-2-yl]cyclopropanol 
• 937400-22-1 (2R,5S)-5-(3,4,5-trifluorophenyl)pyrrolidine-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Prodrug of cinnamide compound

The present invention provides a most suitable prodrug of a cinnamide compound. The prodrug is represented by Formula (I) wherein Ra and Rb each denote a C1-6 alkyl group or the like; Xa denotes a methoxy group or a fluorine atom; Y denotes a phosphono group or the like; and A denotes a cyclic lactam derivative.

TWO CYCLIC OXOMORPHORIN DERIVATIVES

The present invention relates to a compound represented by formula (I): wherein R1 represents a C1-3 alkyl group, R2 represents a hydrogen atom or a C1-3 alkyl group, Ar represents a phenyl group or the like which may be substituted with 1 to 3 substituents, X represents an oxygen atom or the like, n and m are the same or different and integers of 0 to 2, or a pharmacologically acceptable salt, and use thereof as a medicament.

Morpholine type cinnamide compound

The present invention relates to a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein R1, R2, R3, and R4 are the same or different and each represent a hydrogen atom or a C1-6 alkyl group; X1 represents a C1-6 alkylene group that may be substituted; Xa represents a methoxy group or a fluorine atom; Xb represents an oxygen atom or a methylene group, provided that Xb is only an oxygen atom when Xa is a methoxy group; and Ar1 represents an aryl group, pyridinyl group, aryloxy group, or pyridinyloxy group that may have a substituent such as a halogen atom; and to use of the compound or salt as a pharmaceutical agent.