4-(4',5'-dihydro-4',4'-dimethyl-Δ²-oxazolin-2-yl)-5-methyl-3-phenylisoxazole

Base Information

• Chemical Name: 4-(4',5'-dihydro-4',4'-dimethyl-Δ²-oxazolin-2-yl)-5-methyl-3-phenylisoxazole
• CAS No.: 93599-37-2
• Molecular Formula: C₁₅H₁₆N₂O₂
• Molecular Weight: 256.304
• Mol file: 93599-37-2.mol

Synonyms:4-(4',5'-dihydro-4',4'-dimethyl-Δ²-oxazolin-2-yl)-5-methyl-3-phenylisoxazole

Chemical Property of 4-(4',5'-dihydro-4',4'-dimethyl-Δ²-oxazolin-2-yl)-5-methyl-3-phenylisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4',5'-dihydro-4',4'-dimethyl-Δ²-oxazolin-2-yl)-5-methyl-3-phenylisoxazole

There total 3 articles about 4-(4',5'-dihydro-4',4'-dimethyl-Δ²-oxazolin-2-yl)-5-methyl-3-phenylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-methyl-3-phenylisoxazol-4-carboxylic acid (1136-45-4) → 4-(4',5'-dihydro-4',4'-dimethyl-Δ2-oxazolin-2-yl)-5-methyl-3-phenylisoxazole (93599-37-2)

Guidance literature:

DOI:10.1016/0040-4039(84)80036-2

Reference yield:

5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide (99298-89-2) → 4-(4',5'-dihydro-4',4'-dimethyl-Δ2-oxazolin-2-yl)-5-methyl-3-phenylisoxazole (93599-37-2)

Guidance literature:

With thionyl chloride; In chloroform; at 0 - 20 ℃; Yield given;

DOI:10.1021/jo00350a047

Reference yield:

5-methyl-3-phenylisoxazole-4-carbonyl chloride (16883-16-2) → 4-(4',5'-dihydro-4',4'-dimethyl-Δ2-oxazolin-2-yl)-5-methyl-3-phenylisoxazole (93599-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CHCl₃ / 0 - 20 °C

2: thionyl chloride / CHCl₃ / 0 - 20 °C

With thionyl chloride; In chloroform;

DOI:10.1021/jo00350a047

upstream raw materials:

5-methyl-3-phenylisoxazol-4-carboxylic acid

5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide

5-methyl-3-phenylisoxazole-4-carbonyl chloride

Downstream raw materials:

2-[4-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-3-phenyl-isoxazol-5-yl]-1-pyridin-3-yl-ethanol

1-(2-Chloro-phenyl)-2-[4-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-3-phenyl-isoxazol-5-yl]-ethanol

1-(2,5-Dimethoxy-phenyl)-2-[4-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-3-phenyl-isoxazol-5-yl]-ethanol

4-{2-[4-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-3-phenyl-isoxazol-5-yl]-1-hydroxy-ethyl}-benzonitrile