5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide

Base Information

• Chemical Name: 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide
• CAS No.: 99298-89-2
• Molecular Formula: C₁₅H₁₈N₂O₃
• Molecular Weight: 274.32
• Mol file: 99298-89-2.mol

Synonyms:5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide

Chemical Property of 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide

There total 2 articles about 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methyl-3-phenylisoxazol-4-carboxylic acid (1136-45-4) → 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide (99298-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / Ambient temperature

2: CHCl₃ / 0 - 20 °C

With thionyl chloride; In chloroform;

DOI:10.1021/jo00350a047

Reference yield:

5-methyl-3-phenylisoxazole-4-carbonyl chloride (16883-16-2) + 2-Amino-2-methyl-1-propanol (124-68-5) → 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide (99298-89-2)

Guidance literature:

In chloroform; at 0 - 20 ℃;

DOI:10.1021/jo00350a047

Reference yield:

5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide (99298-89-2) → 4-(4',5'-dihydro-4',4'-dimethyl-Δ2-oxazolin-2-yl)-5-methyl-3-phenylisoxazole (93599-37-2)

Guidance literature:

With thionyl chloride; In chloroform; at 0 - 20 ℃; Yield given;

DOI:10.1021/jo00350a047

upstream raw materials:

5-methyl-3-phenylisoxazole-4-carbonyl chloride

2-Amino-2-methyl-1-propanol

5-methyl-3-phenylisoxazol-4-carboxylic acid

Downstream raw materials:

4-(4',5'-dihydro-4',4'-dimethyl-Δ²-oxazolin-2-yl)-5-methyl-3-phenylisoxazole

4-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-5-ethyl-3-phenyl-isoxazole

C₁₅H₁₅⁽²⁾HN₂O₂

C₁₆H₁₇⁽²⁾HN₂O₂