ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate

Base Information

Chemical Name:ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate
CAS No.:1444001-42-6
Molecular Formula:C₂₈H₃₅N₅O₈S
Molecular Weight:601.681
Hs Code.:

ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate

Synonyms:ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate

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Chemical Property of ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate

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Technology Process of ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate

There total 7 articles about ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1444001-37-9
ethyl 1-(4-((S)-5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate

: 302964-20-1
2-tert-butoxycarbonylamino-1,3-thiazole-5-carboxylic acid chloride

: 1444001-42-6
ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 15h;
DOI:10.1016/j.ejmech.2013.03.056

Reference yield:

: 1444001-32-4
ethyl 1-(4-((S)-5-((1,3-dioxoisoindolin-2-yl)methyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate

: 1444001-42-6
ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 2.5 h / 0 - 80 °C

2: triethylamine / dichloromethane / 15 h / 0 - 20 °C

With hydrazine hydrate; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2013.03.056

Reference yield:

: 3731-16-6
3-carboethoxy-2-pyridone

: 1444001-42-6
ethyl 1-(4-((S)-5-((2-((tert-butoxycarbonyl)amino)thiazole-5-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-3-methyl-2-oxopiperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium / 1 h / Reflux

2.1: sodium hydride / mineral oil; 1-methyl-pyrrolidin-2-one / 1 h

2.2: 18 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr

4.1: ethanol / 15 h / Reflux

5.1: dmap / tetrahydrofuran / 15 h / 60 °C

6.1: hydrazine hydrate / ethanol / 2.5 h / 0 - 80 °C

7.1: triethylamine / dichloromethane / 15 h / 0 - 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; sodium; sodium hydride; hydrazine hydrate; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; mineral oil;
DOI:10.1016/j.ejmech.2013.03.056