2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-biphenyl-4-yl]-N-methyl-N-phenethyl-acetamide

Base Information

Chemical Name:2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-biphenyl-4-yl]-N-methyl-N-phenethyl-acetamide
CAS No.:181268-56-4
Molecular Formula:C₄₀H₄₃NO₂Si
Molecular Weight:597.872
Hs Code.:

Synonyms:2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-biphenyl-4-yl]-N-methyl-N-phenethyl-acetamide

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Chemical Property of 2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-biphenyl-4-yl]-N-methyl-N-phenethyl-acetamide

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Technology Process of 2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-biphenyl-4-yl]-N-methyl-N-phenethyl-acetamide

There total 12 articles about 2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-biphenyl-4-yl]-N-methyl-N-phenethyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35450-36-3
methyl 2-bromo-5-methoxybenzoate

: 181268-56-4
2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-biphenyl-4-yl]-N-methyl-N-phenethyl-acetamide

Guidance literature:: Multi-step reaction with 11 steps

1: 91 percent / K₂CO₃, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene; methanol; H₂O / 24 h / 80 °C

2: 60 percent / HBr, AcOH / 24 h / 118 °C

3: 81 percent / HCl / Ambient temperature

4: 98.7 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

5: 78 percent / LiCl, PdCl₂(Ph₃P)2 / dimethylformamide / 12 h / Ambient temperature

6: DIBAL-H / CH₂Cl₂ / 4 h / Ambient temperature

7: imidazole / dimethylformamide / 12 h / Ambient temperature

8: 1.) 9-BBN, 2.) 1 N aq. NaOH, 30percent H₂O₂ / 1.) THF, RT, 12 h, 2.) THF, 30 min

9: CrO₃, H₂SO₄ / acetone / 0 °C

10: CH₂Cl₂ / 1 h / Ambient temperature

11: CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; 1H-imidazole; chromium(VI) oxide; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; hydrogen bromide; dihydrogen peroxide; diisobutylaluminium hydride; potassium carbonate; acetic acid; lithium chloride; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jm9506985

Reference yield:

: 52108-18-6
4-hydroxy-biphenyl-2-carboxylic acid

: 181268-56-4
2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-biphenyl-4-yl]-N-methyl-N-phenethyl-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: 81 percent / HCl / Ambient temperature

2: 98.7 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

3: 78 percent / LiCl, PdCl₂(Ph₃P)2 / dimethylformamide / 12 h / Ambient temperature

4: DIBAL-H / CH₂Cl₂ / 4 h / Ambient temperature

5: imidazole / dimethylformamide / 12 h / Ambient temperature

6: 1.) 9-BBN, 2.) 1 N aq. NaOH, 30percent H₂O₂ / 1.) THF, RT, 12 h, 2.) THF, 30 min

7: CrO₃, H₂SO₄ / acetone / 0 °C

8: CH₂Cl₂ / 1 h / Ambient temperature

9: CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; 1H-imidazole; chromium(VI) oxide; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; sulfuric acid; dihydrogen peroxide; diisobutylaluminium hydride; lithium chloride; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm9506985

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 181268-56-4
2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-biphenyl-4-yl]-N-methyl-N-phenethyl-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole / dimethylformamide / 12 h / Ambient temperature

2: 1.) 9-BBN, 2.) 1 N aq. NaOH, 30percent H₂O₂ / 1.) THF, RT, 12 h, 2.) THF, 30 min

3: CrO₃, H₂SO₄ / acetone / 0 °C

4: CH₂Cl₂ / 1 h / Ambient temperature

5: CH₂Cl₂ / 24 h / Ambient temperature

With 1H-imidazole; chromium(VI) oxide; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; sulfuric acid; dihydrogen peroxide; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm9506985