[2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]methyl di-tert-butyl phosphate

Base Information

Chemical Name:[2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]methyl di-tert-butyl phosphate
CAS No.:1367455-49-9
Molecular Formula:C₃₂H₃₅F₂N₄O₅P
Molecular Weight:624.624
Hs Code.:

Synonyms:[2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]methyl di-tert-butyl phosphate

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Chemical Property of [2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]methyl di-tert-butyl phosphate

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Technology Process of [2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]methyl di-tert-butyl phosphate

There total 9 articles about [2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]methyl di-tert-butyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1367455-82-0
[2-amino-6-(2-chloromethyl-4,5-difluorophenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone

: 68695-48-7
di-tert-butyl phosphoric acid tetra-n-butylammonium salt

: 1367455-49-9
[2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]methyl di-tert-butyl phosphate

Guidance literature:: In acetonitrile; at 80 ℃; for 2h;

Reference yield:

: 1228311-57-6
[2-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone

: 1367455-49-9
[2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]methyl di-tert-butyl phosphate

Guidance literature:: Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; water / 0.5 h / 120 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 2 h / 25 °C

3: acetonitrile / 2 h / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; potassium carbonate; In ethanol; dichloromethane; water; acetonitrile; 1: |Suzuki Coupling;

Reference yield:

: 13086-84-5
di-tert-butyl phosphite

: 1367455-49-9
[2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]methyl di-tert-butyl phosphate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium permanganate; potassium hydrogencarbonate / water / 1.42 h / 0 - 60 °C

2: water; acetone / Cooling with ice

3: acetonitrile / 2 h / 80 °C

With potassium permanganate; potassium hydrogencarbonate; In water; acetone; acetonitrile;