[2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]-methyl dihydrogenphosphate

Base Information

Chemical Name:[2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]-methyl dihydrogenphosphate
CAS No.:1367455-50-2
Molecular Formula:C₂₄H₁₉F₂N₄O₅P
Molecular Weight:512.409
Hs Code.:

Synonyms:[2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]-methyl dihydrogenphosphate

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Chemical Property of [2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]-methyl dihydrogenphosphate

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Technology Process of [2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]-methyl dihydrogenphosphate

There total 8 articles about [2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]-methyl dihydrogenphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1367455-49-9
[2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]methyl di-tert-butyl phosphate

: 1367455-50-2
[2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]-methyl dihydrogenphosphate

Guidance literature:: With trifluoroacetic acid; at 25 ℃; for 1h;

Reference yield:

: 1367455-82-0
[2-amino-6-(2-chloromethyl-4,5-difluorophenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone

: 1367455-50-2
[2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]-methyl dihydrogenphosphate

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 2 h / 80 °C

2: trifluoroacetic acid / 1 h / 25 °C

With trifluoroacetic acid; In acetonitrile;

Reference yield:

: 1228311-57-6
[2-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone

: 1367455-50-2
[2-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]-4,5-difluorophenyl]-methyl dihydrogenphosphate

Guidance literature:: Multi-step reaction with 4 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; water / 0.5 h / 120 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 2 h / 25 °C

3: acetonitrile / 2 h / 80 °C

4: trifluoroacetic acid / 1 h / 25 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; potassium carbonate; trifluoroacetic acid; In ethanol; dichloromethane; water; acetonitrile; 1: |Suzuki Coupling;