Technology Process of Boc-Glu(OBu-t)-azoAla-Gly-Gly-OEt
There total 3 articles about Boc-Glu(OBu-t)-azoAla-Gly-Gly-OEt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
In
chloroform;
1) ice-cooling, 3 h; 2) room temperature, 24 h;
DOI:10.1246/bcsj.67.1380
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 27 percent / Et3N, 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CHCl3 / 1) ice-cooling, 3 h; 2) room temperature, 24 h
2: aq. HCl / dioxane / 0.5 h / Ambient temperature
3: 60 percent / Et3N, 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CHCl3 / 1) ice-cooling, 3 h; 2) room temperature, 24 h
With
hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
In
1,4-dioxane; chloroform;
DOI:10.1246/bcsj.67.1380
- Guidance literature:
-
Multi-step reaction with 2 steps
1: aq. HCl / dioxane / 0.5 h / Ambient temperature
2: 60 percent / Et3N, 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CHCl3 / 1) ice-cooling, 3 h; 2) room temperature, 24 h
With
hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
In
1,4-dioxane; chloroform;
DOI:10.1246/bcsj.67.1380