(3-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid benzyl ester methyl ester

Base Information

Chemical Name:(3-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid benzyl ester methyl ester
CAS No.:86530-02-1
Molecular Formula:C₂₈H₅₀NO₆PSi₂
Molecular Weight:583.853
Hs Code.:

(3-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid benzyl ester methyl ester

Synonyms:(3-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid benzyl ester methyl ester

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Chemical Property of (3-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid benzyl ester methyl ester

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Technology Process of (3-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid benzyl ester methyl ester

There total 7 articles about (3-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid benzyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 710-09-8
methyl-phosphonic acid benzyl methyl ester

: 74288-34-9,86560-66-9
{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-acetic acid methyl ester

: 86530-02-1
(3-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid benzyl ester methyl ester

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 - 25 ℃;
DOI:10.1016/S0040-4039(00)81403-3

Reference yield:

: 19236-58-9
dibenzyl methylphosphonate

: 86530-02-1
(3-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid benzyl ester methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1N NaOH / tetrahydrofuran / 48 h

3: 45 percent / nBuLi / tetrahydrofuran / -78 - 25 °C

With sodium hydroxide; n-butyllithium; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)81403-3

Reference yield:

: 538-60-3
dibenzyl hydrogen phosphite

: 86530-02-1
(3-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid benzyl ester methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / dimethylformamide / 0 °C

2: 1N NaOH / tetrahydrofuran / 48 h

4: 45 percent / nBuLi / tetrahydrofuran / -78 - 25 °C

With sodium hydroxide; n-butyllithium; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)81403-3