rac-4-(5-bromo-2-fluoro-phenyl)-4-difluoromethyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester

Base Information

Chemical Name:rac-4-(5-bromo-2-fluoro-phenyl)-4-difluoromethyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester
CAS No.:1397683-71-4
Molecular Formula:C₁₄H₁₅BrF₃NO₅S
Molecular Weight:446.242
Hs Code.:

Synonyms:rac-4-(5-bromo-2-fluoro-phenyl)-4-difluoromethyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester

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Chemical Property of rac-4-(5-bromo-2-fluoro-phenyl)-4-difluoromethyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester

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Technology Process of rac-4-(5-bromo-2-fluoro-phenyl)-4-difluoromethyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester

There total 1 articles about rac-4-(5-bromo-2-fluoro-phenyl)-4-difluoromethyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1397683-71-4
rac-4-(5-bromo-2-fluoro-phenyl)-4-difluoromethyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:

Reference yield: 67.0%

: 1397683-71-4
rac-4-(5-bromo-2-fluoro-phenyl)-4-difluoromethyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester

: 39846-84-9
5-nitro-1H-pyrazole-3-carboxylic acid ethyl ester

: 1397683-72-5
C₁₅H₁₄BrF₃N₄O₄

Guidance literature:: rac-4-(5-bromo-2-fluoro-phenyl)-4-difluoromethyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester; 5-nitro-1H-pyrazole-3-carboxylic acid ethyl ester; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 - 60 ℃; for 18h;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

With sodium carbonate; In dichloromethane; water;

Reference yield:

: 1397683-71-4
rac-4-(5-bromo-2-fluoro-phenyl)-4-difluoromethyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester

: 1397683-74-7
rac-2-amino-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 18 h / 20 - 60 °C

1.2: 2 h / 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 150 °C / Sealed tube; Microwave irradiation

3.1: hydrogen / ruthenium(IV) oxide / methanol / 50 °C

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; ruthenium(IV) oxide; In methanol; acetonitrile;