rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

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Chemical Name:rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one
CAS No.:1397683-75-8
Molecular Formula:C₁₃H₉BrF₃N₃O
Molecular Weight:360.133
Hs Code.:

Synonyms:rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

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Chemical Property of rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

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Technology Process of rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

There total 4 articles about rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1397683-74-7
rac-2-amino-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

: 1397683-75-8
rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: rac-2-amino-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one; With sulfuric acid; In ethanol; at 90 ℃;

With sodium nitrite; In ethanol; at 90 ℃; for 0.333333h;

Reference yield:

: 1397683-71-4
rac-4-(5-bromo-2-fluoro-phenyl)-4-difluoromethyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester

: 1397683-75-8
rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 18 h / 20 - 60 °C

1.2: 2 h / 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 150 °C / Sealed tube; Microwave irradiation

3.1: hydrogen / ruthenium(IV) oxide / methanol / 50 °C

4.1: sulfuric acid / ethanol / 90 °C

4.2: 0.33 h / 90 °C

With sulfuric acid; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; ruthenium(IV) oxide; In methanol; ethanol; acetonitrile;

Reference yield:

: 1397683-72-5
C₁₅H₁₄BrF₃N₄O₄

: 1397683-75-8
rac-6-(5-bromo-2-fluoro-phenyl)-6-difluoromethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 150 °C / Sealed tube; Microwave irradiation

2.1: hydrogen / ruthenium(IV) oxide / methanol / 50 °C

3.1: sulfuric acid / ethanol / 90 °C

3.2: 0.33 h / 90 °C

With sulfuric acid; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; ruthenium(IV) oxide; In methanol; ethanol; acetonitrile;