N-({4-amino-2-(methylthio)furo[2,3-d]pyrimidin-5-yl}methyl)-4-nitro-N-(2-nitrophenyl)benzenesulfonamide

Base Information

Chemical Name:N-({4-amino-2-(methylthio)furo[2,3-d]pyrimidin-5-yl}methyl)-4-nitro-N-(2-nitrophenyl)benzenesulfonamide
CAS No.:1383579-53-0
Molecular Formula:C₂₀H₁₆N₆O₇S₂
Molecular Weight:516.515
Hs Code.:

Synonyms:N-({4-amino-2-(methylthio)furo[2,3-d]pyrimidin-5-yl}methyl)-4-nitro-N-(2-nitrophenyl)benzenesulfonamide

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Chemical Property of N-({4-amino-2-(methylthio)furo[2,3-d]pyrimidin-5-yl}methyl)-4-nitro-N-(2-nitrophenyl)benzenesulfonamide

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Technology Process of N-({4-amino-2-(methylthio)furo[2,3-d]pyrimidin-5-yl}methyl)-4-nitro-N-(2-nitrophenyl)benzenesulfonamide

There total 3 articles about N-({4-amino-2-(methylthio)furo[2,3-d]pyrimidin-5-yl}methyl)-4-nitro-N-(2-nitrophenyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1383579-32-5
4-amino-5-(hydroxymethyl)-2-(methylthio)furo[2,3-d]pyrimidine

: 299968-59-5
4-nitro-N-(2-nitrophenyl)benzenesulfonamide

: 1383579-53-0
N-({4-amino-2-(methylthio)furo[2,3-d]pyrimidin-5-yl}methyl)-4-nitro-N-(2-nitrophenyl)benzenesulfonamide

Guidance literature:: 4-nitro-N-(2-nitrophenyl)benzenesulfonamide; With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 ℃; for 0.166667h;

4-amino-5-(hydroxymethyl)-2-(methylthio)furo[2,3-d]pyrimidine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1055/s-0031-1290524

Reference yield:

: 1198054-16-8
ethyl 4-amino-2-(methylthio)furo[2,3-d]pyrimidine-5-carboxylate

: 1383579-53-0
N-({4-amino-2-(methylthio)furo[2,3-d]pyrimidin-5-yl}methyl)-4-nitro-N-(2-nitrophenyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -50 - 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0 - 20 °C

With lithium aluminium tetrahydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2.1: Mitsunobu reaction / 2.2: Mitsunobu reaction;
DOI:10.1055/s-0031-1290524

Reference yield:

: 88-74-4
2-nitro-aniline

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1383579-53-0
N-({4-amino-2-(methylthio)furo[2,3-d]pyrimidin-5-yl}methyl)-4-nitro-N-(2-nitrophenyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; dmap / 6 h / 60 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0 - 20 °C

With pyridine; dmap; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2.1: Mitsunobu reaction / 2.2: Mitsunobu reaction;
DOI:10.1055/s-0031-1290524