3-(2-(4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)pyrimidin-2-yloxy)ethyl)-6-(4-(trifluoromethoxy)phenyl)benzo[d][1,2,3]triazin-4(3H)-one

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Chemical Name:3-(2-(4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)pyrimidin-2-yloxy)ethyl)-6-(4-(trifluoromethoxy)phenyl)benzo[d][1,2,3]triazin-4(3H)-one
CAS No.:1411979-90-2
Molecular Formula:C₂₅H₁₈F₃N₇O₄
Molecular Weight:537.458
Hs Code.:

Synonyms:3-(2-(4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)pyrimidin-2-yloxy)ethyl)-6-(4-(trifluoromethoxy)phenyl)benzo[d][1,2,3]triazin-4(3H)-one

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Chemical Property of 3-(2-(4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)pyrimidin-2-yloxy)ethyl)-6-(4-(trifluoromethoxy)phenyl)benzo[d][1,2,3]triazin-4(3H)-one

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Technology Process of 3-(2-(4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)pyrimidin-2-yloxy)ethyl)-6-(4-(trifluoromethoxy)phenyl)benzo[d][1,2,3]triazin-4(3H)-one

There total 6 articles about 3-(2-(4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)pyrimidin-2-yloxy)ethyl)-6-(4-(trifluoromethoxy)phenyl)benzo[d][1,2,3]triazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1411982-36-9
C₂₁H₁₆F₃N₇O₄

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1411979-90-2
3-(2-(4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)pyrimidin-2-yloxy)ethyl)-6-(4-(trifluoromethoxy)phenyl)benzo[d][1,2,3]triazin-4(3H)-one

Guidance literature:: With pyridine; In toluene; at 100 ℃; for 48h;

Reference yield:

: 890092-43-0
6-bromobenzo[d][1,2,3]triazin-4(3H)-one

: 1411979-90-2
3-(2-(4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)pyrimidin-2-yloxy)ethyl)-6-(4-(trifluoromethoxy)phenyl)benzo[d][1,2,3]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

2: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.33 h / 140 °C / Microwave irradiation

3: sodium hydride / tetrahydrofuran; mineral oil / 60 °C

4: potassium carbonate; hydroxylamine hydrochloride / ethanol / 20 - 70 °C

5: pyridine / toluene / 48 h / 100 °C

With pyridine; hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; mineral oil; 2: Suzuki Coupling;

Reference yield:

: 16313-66-9
5-bromoanthranilamide

: 1411979-90-2
3-(2-(4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)pyrimidin-2-yloxy)ethyl)-6-(4-(trifluoromethoxy)phenyl)benzo[d][1,2,3]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 0.5 h

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

3: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.33 h / 140 °C / Microwave irradiation

4: sodium hydride / tetrahydrofuran; mineral oil / 60 °C

5: potassium carbonate; hydroxylamine hydrochloride / ethanol / 20 - 70 °C

6: pyridine / toluene / 48 h / 100 °C

With pyridine; hydrogenchloride; hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; potassium carbonate; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil; 3: Suzuki Coupling;