N-(5-(2-(((4-chloro-2-methylphenyl)(phenyl)methyl)amino)-2-oxoethyl)-2-hydroxyphenyl)-2,4-dimethylnicotinamide

Base Information

Chemical Name:N-(5-(2-(((4-chloro-2-methylphenyl)(phenyl)methyl)amino)-2-oxoethyl)-2-hydroxyphenyl)-2,4-dimethylnicotinamide
CAS No.:1422169-77-4
Molecular Formula:C₃₀H₂₈ClN₃O₃
Molecular Weight:514.024
Hs Code.:

Synonyms:N-(5-(2-(((4-chloro-2-methylphenyl)(phenyl)methyl)amino)-2-oxoethyl)-2-hydroxyphenyl)-2,4-dimethylnicotinamide

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Chemical Property of N-(5-(2-(((4-chloro-2-methylphenyl)(phenyl)methyl)amino)-2-oxoethyl)-2-hydroxyphenyl)-2,4-dimethylnicotinamide

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Technology Process of N-(5-(2-(((4-chloro-2-methylphenyl)(phenyl)methyl)amino)-2-oxoethyl)-2-hydroxyphenyl)-2,4-dimethylnicotinamide

There total 2 articles about N-(5-(2-(((4-chloro-2-methylphenyl)(phenyl)methyl)amino)-2-oxoethyl)-2-hydroxyphenyl)-2,4-dimethylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 55314-30-2
2,4-dimethylnicotinic acid

: 1422169-76-3
2-(3-amino-4-hydroxyphenyl)-N-((4-chloro-2-methylphenyl)(phenyl)methyl)acetamide

: 1422169-77-4
N-(5-(2-(((4-chloro-2-methylphenyl)(phenyl)methyl)amino)-2-oxoethyl)-2-hydroxyphenyl)-2,4-dimethylnicotinamide

Guidance literature:: 2,4-dimethylnicotinic acid; With thionyl chloride; In dichloromethane; for 1h; Reflux;

2-(3-amino-4-hydroxyphenyl)-N-((4-chloro-2-methylphenyl)(phenyl)methyl)acetamide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1422169-75-2
N-((4-chloro-2-methylphenyl)(phenyl)methyl)-2-(4-hydroxy-3-nitrophenyl)acetamide

: 1422169-77-4
N-(5-(2-(((4-chloro-2-methylphenyl)(phenyl)methyl)amino)-2-oxoethyl)-2-hydroxyphenyl)-2,4-dimethylnicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc; ammonium chloride / water; ethanol / 3 h / 60 °C

2.1: thionyl chloride / dichloromethane / 1 h / Reflux

2.2: 3 h / 20 °C

With thionyl chloride; ammonium chloride; zinc; In ethanol; dichloromethane; water;