(7S,10aS)-7-benzyl-2,10a-dimethyl-3-morpholino-7,8-dihydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-5,10(10aH)-dione

Base Information

Chemical Name:(7S,10aS)-7-benzyl-2,10a-dimethyl-3-morpholino-7,8-dihydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-5,10(10aH)-dione
CAS No.:1407675-23-3
Molecular Formula:C₂₃H₂₅N₃O₄
Molecular Weight:407.469
Hs Code.:

Synonyms:(7S,10aS)-7-benzyl-2,10a-dimethyl-3-morpholino-7,8-dihydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-5,10(10aH)-dione

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Chemical Property of (7S,10aS)-7-benzyl-2,10a-dimethyl-3-morpholino-7,8-dihydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-5,10(10aH)-dione

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Technology Process of (7S,10aS)-7-benzyl-2,10a-dimethyl-3-morpholino-7,8-dihydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-5,10(10aH)-dione

There total 3 articles about (7S,10aS)-7-benzyl-2,10a-dimethyl-3-morpholino-7,8-dihydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-5,10(10aH)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 108-31-6
maleic anhydride

: 1407674-68-3
(3S,5S)-5-benzyl-3-methyl-3-(4-methyl-5-morpholinooxazol-2-yl)morpholin-2-one

: 1407675-23-3
(7S,10aS)-7-benzyl-2,10a-dimethyl-3-morpholino-7,8-dihydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-5,10(10aH)-dione

Guidance literature:: In toluene; at 110 ℃; for 6h; Molecular sieve;
DOI:10.1021/jo4000702

Reference yield: 71.0%

: 108-31-6
maleic anhydride

: 1355545-47-9
C₁₂H₁₃NO₂

: 1248297-74-6
C₈H₁₂N₂O₂

: 1407675-23-3
(7S,10aS)-7-benzyl-2,10a-dimethyl-3-morpholino-7,8-dihydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-5,10(10aH)-dione

Guidance literature:: C₁₂H₁₃NO₂; C₈H₁₂N₂O₂; With phenylphosphinic acid; In 2,2,2-trifluoroethanol; at 20 ℃;

maleic anhydride; With triethylamine; In 2,2,2-trifluoroethanol; toluene; at 110 ℃; Molecular sieve;
DOI:10.1021/jo4000702

Reference yield:

: 1355545-47-9
C₁₂H₁₃NO₂

: 1407675-23-3
(7S,10aS)-7-benzyl-2,10a-dimethyl-3-morpholino-7,8-dihydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-5,10(10aH)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: phenylphosphinic acid / 2,2,2-trifluoroethanol / 1 h / 20 °C

2: toluene / 6 h / 110 °C / Molecular sieve

With phenylphosphinic acid; In 2,2,2-trifluoroethanol; toluene; 1: |Ugi Condensation;
DOI:10.1021/jo4000702