(3S,5S)-5-benzyl-3-methyl-3-(4-methyl-5-morpholinooxazol-2-yl)morpholin-2-one

Base Information

• Chemical Name: (3S,5S)-5-benzyl-3-methyl-3-(4-methyl-5-morpholinooxazol-2-yl)morpholin-2-one
• CAS No.: 1407674-68-3
• Molecular Formula: C₂₀H₂₅N₃O₄
• Molecular Weight: 371.436

Synonyms:(3S,5S)-5-benzyl-3-methyl-3-(4-methyl-5-morpholinooxazol-2-yl)morpholin-2-one

Chemical Property of (3S,5S)-5-benzyl-3-methyl-3-(4-methyl-5-morpholinooxazol-2-yl)morpholin-2-one

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of (3S,5S)-5-benzyl-3-methyl-3-(4-methyl-5-morpholinooxazol-2-yl)morpholin-2-one

There total 2 articles about (3S,5S)-5-benzyl-3-methyl-3-(4-methyl-5-morpholinooxazol-2-yl)morpholin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-isocyano-1-morpholinopropan-1-one + C12H13NO2 (1355545-47-9) → (3S,5S)-5-benzyl-3-methyl-3-(4-methyl-5-morpholinooxazol-2-yl)morpholin-2-one (1407674-68-3)

Guidance literature:

With phenylphosphinic acid; In 2,2,2-trifluoroethanol; at 20 ℃; for 1h; stereoselective reaction;

DOI:10.1055/s-0032-1316549

Reference yield: 92.0%

C12H13NO2 (1355545-47-9) + C8H12N2O2 (1248297-74-6) → (3S,5S)-5-benzyl-3-methyl-3-(4-methyl-5-morpholinooxazol-2-yl)morpholin-2-one (1407674-68-3)

Guidance literature:

With phenylphosphinic acid; In 2,2,2-trifluoroethanol; at 20 ℃; for 1h; diastereoselective reaction;

DOI:10.1021/jo4000702

Reference yield: 78.0%

maleic anhydride (108-31-6) + (3S,5S)-5-benzyl-3-methyl-3-(4-methyl-5-morpholinooxazol-2-yl)morpholin-2-one (1407674-68-3) → (7S,10aS)-7-benzyl-2,10a-dimethyl-3-morpholino-7,8-dihydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-5,10(10aH)-dione (1407675-23-3)

Guidance literature:

In toluene; at 110 ℃; for 6h; Molecular sieve;

DOI:10.1021/jo4000702

upstream raw materials:

C₁₂H₁₃NO₂

C₈H₁₂N₂O₂

Downstream raw materials:

(7S,10aS)-7-benzyl-2,10a-dimethyl-3-morpholino-7,8-dihydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-5,10(10aH)-dione

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