Technology Process of N-(4-difluoromethyl-3-pyridin-4-yl-benzyl)-2,2,2-trifluoro-acetamide hydrochloride
There total 5 articles about N-(4-difluoromethyl-3-pyridin-4-yl-benzyl)-2,2,2-trifluoro-acetamide hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-difluoromethyl-3-pyridin-4-yl-benzylamine; trifluoroacetic anhydride;
In
acetic acid butyl ester;
at 0 ℃;
for 4h;
With
hydrogenchloride;
In
diethyl ether; acetic acid butyl ester;
for 0.333333h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium azide / N,N-dimethyl-formamide / 20 °C
2.1: 2,2-difluoro-1,3-dimethyl-imidazolidine / acetonitrile / 84 °C
3.1: triphenylphosphine; water / tetrahydrofuran / 20 °C
3.2: 0 °C
3.3: pH 10
4.1: sodium hydrogencarbonate / 0.33 h / Inert atmosphere
4.2: 22 h / 85 °C
5.1: acetic acid butyl ester / 4 h / 0 °C
5.2: 0.33 h
With
sodium azide; water; sodium hydrogencarbonate; triphenylphosphine; 2,2-difluoro-1,3-dimethyl-imidazolidine;
In
tetrahydrofuran; acetic acid butyl ester; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 2,2-difluoro-1,3-dimethyl-imidazolidine / acetonitrile / 84 °C
2.1: triphenylphosphine; water / tetrahydrofuran / 20 °C
2.2: 0 °C
2.3: pH 10
3.1: sodium hydrogencarbonate / 0.33 h / Inert atmosphere
3.2: 22 h / 85 °C
4.1: acetic acid butyl ester / 4 h / 0 °C
4.2: 0.33 h
With
water; sodium hydrogencarbonate; triphenylphosphine; 2,2-difluoro-1,3-dimethyl-imidazolidine;
In
tetrahydrofuran; acetic acid butyl ester; acetonitrile;
