2-(3-chlorophenyl)-1-(cyclohexylamino)pyrrolo[1,2-a]quinoline-3-carbonitrile

Base Information

• Chemical Name: 2-(3-chlorophenyl)-1-(cyclohexylamino)pyrrolo[1,2-a]quinoline-3-carbonitrile
• CAS No.: 1637489-71-4
• Molecular Formula: C₂₅H₂₂ClN₃
• Molecular Weight: 399.923
• Mol file: 1637489-71-4.mol

Synonyms:2-(3-chlorophenyl)-1-(cyclohexylamino)pyrrolo[1,2-a]quinoline-3-carbonitrile

Chemical Property of 2-(3-chlorophenyl)-1-(cyclohexylamino)pyrrolo[1,2-a]quinoline-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(3-chlorophenyl)-1-(cyclohexylamino)pyrrolo[1,2-a]quinoline-3-carbonitrile

There total 3 articles about 2-(3-chlorophenyl)-1-(cyclohexylamino)pyrrolo[1,2-a]quinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

quinoline (91-22-5) + Cyclohexyl isocyanide (931-53-3) + 2-(3-chlorobenzylidene)malononitrile (2972-73-8) → 2-(3-chlorophenyl)-1-(cyclohexylamino)pyrrolo[1,2-a]quinoline-3-carbonitrile (1637489-71-4)

Guidance literature:

In neat (no solvent); at 70 ℃; for 0.583333h;

DOI:10.3184/174751914X14031091272010

Reference yield:

C26H23ClN4 → 2-(3-chlorophenyl)-1-(cyclohexylamino)pyrrolo[1,2-a]quinoline-3-carbonitrile (1637489-71-4)

Guidance literature:

With silica gel; In ethyl acetate; Petroleum ether;

DOI:10.1002/jhet.1913

Reference yield:

m-Chlorobenzaldehyde (587-04-2) → 2-(3-chlorophenyl)-1-(cyclohexylamino)pyrrolo[1,2-a]quinoline-3-carbonitrile (1637489-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: neat (no solvent) / 0.67 h / 70 °C

2: neat (no solvent) / 0.58 h / 70 °C

In neat (no solvent); 1: |Knoevenagel Condensation;

DOI:10.3184/174751914X14031091272010

upstream raw materials:

quinoline

Cyclohexyl isocyanide

2-(3-chlorobenzylidene)malononitrile

m-Chlorobenzaldehyde