2972-73-8

Usage

Uses

Used in Pharmaceutical Industry:
(3-chlorobenzylidene)propanedinitrile is used as a chemical intermediate for the production of various pharmaceuticals. Its unique structure allows it to be a key component in the synthesis of drugs with specific therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, (3-chlorobenzylidene)propanedinitrile serves as a chemical intermediate, contributing to the development of compounds used in agriculture for pest control and crop protection.
Used in Organic Synthesis:
(3-chlorobenzylidene)propanedinitrile is utilized as a reagent in organic synthesis, facilitating the creation of a wide range of organic compounds for various applications.
Used in Materials Science:
Its potential use in materials science stems from the compound's ability to contribute to the development of new materials with specific properties, such as those with enhanced stability or reactivity.
Used as a Precursor for Aromatic Compounds:
(3-chlorobenzylidene)propanedinitrile also acts as a precursor for the synthesis of other aromatic compounds, which are important in various chemical and industrial processes.
It is crucial to handle and use (3-chlorobenzylidene)propanedinitrile with care due to its potential toxic or harmful effects if not properly managed.

Upstream product

• 587-04-2 m-Chlorobenzaldehyde 
• 109-77-3 malononitrile 
• 98-86-2 acetophenone 
• 3395-80-0 1,1-dimethoxy-1-(3-chlorophenyl)methane 

Downstream Products

• 89864-92-6 4-(3-Chloro-phenyl)-5-trimethylsilanyl-1H-pyrazole-3-carbonitrile 
• 41470-37-5 Dicyanomethyl-anion 
• 587-04-2 m-Chlorobenzaldehyde 
• 128061-88-1 5-Amino-7-(3-chloro-phenyl)-2-[1-(3-chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-6,8-dicarbonitrile 
• 77491-00-0 2-(3-chlorophenylmethylene)malononitrile 
• 1026936-20-8 6-amino-4-(3-chloro-phenyl)-6'-dimethylamino-3-phenyl-[2,3']bipyridinyl-5-carbonitrile 
• 1027087-85-9 6-amino-4-(3-chloro-phenyl)-3-(4-dimethylamino-phenyl)-6'-morpholin-4-yl-[2,3']bipyridinyl-5-carbonitrile 
• 929698-64-6 2-amino-4-(3-chloro-phenyl)-8-methoxy-5,6-dihydro-benzo[h]quinoline-3-carbonitrile 
• 201807-83-2 6-amino-4-(3-chlorophenyl)-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile 
• 23767-67-1 3-(3-chlorophenyl)-1,1,2,2-tetracyanocyclopropane 

Relevant academic research and scientific papers

Reversible Phase Transfer of Carbon Dots between an Organic Phase and Aqueous Solution Triggered by CO2

Carbon dots (CDs) have attracted increasing attention in applications such as bio-imaging, sensors, catalysis, and drug delivery. However, unlike metallic and semiconductor nanoparticles, the transfer of CDs between polar and non-polar phases is little un

Effecting structural diversity in a series of Co(ii)-organic frameworks by the interplay between rigidity of a dicarboxylate and flexibility of bis(tridentate) spanning ligands

In a one-pot self-assembly reaction of Co(OAc)2·4H2O, thiophene-2,5-dicarboxylic acid (H2tdc) and four different bis(tridentate) polypyridyl spanning ligands under ambient conditions, a series of structurally diverse metal-organic frameworks has been synt

First organocatalytic asymmetric synthesis of 1-Benzamido-1,4-Dihydropyridine Derivatives

Preliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1,4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of β-isocupreidine catalyst are reported. The m

Synthesis, molecular docking, and in silico ADME prediction of some fused pyrazolo[1,5-a]pyrimidine and pyrazole derivatives as potential antimicrobial agents

Twenty compounds of pyrazolo[1,5-a]pyrimidines 14a–j and pyrazole derivatives as Schiff bases 16a–j have been synthesized by the reaction of 5-amino-pyrazole derivatives 9a, b with 2-(arylidene)malononitriles 10a–e or various aldehydes 15a–e, respectively

Effect of supramolecular polymeric aggregation in room temperature ionic liquids (RTILs) on catalytic activity in the synthesis of 4H-chromene derivatives and Knoevenagel condensation

RTILs exhibit supramolecular self-assembled polymeric aggregation due to noncovalent interactions. The influence of the aggregation behaviour of RTILs on catalytic activity is evident but still poorly understood. The present work focuses on establishing a

Introduction of succinimide as a green and sustainable organo-catalyst for the synthesis of arylidene malononitrile and tetrahydrobenzo[b] pyran derivatives

Aim and Objective: In this work, we tried to introduce a non-toxic and stable organic compound named succinimide as a green and efficient organo-catalyst for the promotion of the synthesis of arylidene malononitrile and tetrahydrobenzo[b]pyran derivatives

Development of an efficient, one-pot, multicomponent protocol for synthesis of 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives

A one-pot quick and efficient multicomponent reaction has been developed for the synthesis of a new series of functionalized 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives using 30 mol% ammonium acetate in ethanol as solvent. This economical protocol

Phosphine-Catalyzed (4 + 2) Annulation of δ-Sulfonamido-Substituted Enones with 1,1-Dicyanoalkenes: Synthesis of Piperidine Derivatives

The δ-sulfonamido-substituted enones were employed as phosphine acceptor in phosphine-catalyzed (4 + 2) annulation of 1,1-dicyanoalkenes. They served as a four-membered synthon to react with 1,1-dicyanoalkenes under mild reaction conditions, producing pip

Supramolecular polymeric aggregation behavior and its impact on catalytic properties of imidazolium based hydrophilic ionic liquids

Ionic Liquids (ILs) self-assemble to form supramolecular polymeric clusters/aggregates. The aggregation behavior of ILs influences its activity in the organic synthesis. However, the precise role of ILs in organic reactions is still unknown. It is, therefore, important to comprehend the supramolecular polymeric aggregation behavior of ILs. We are exploring the supramolecular polymeric aggregation behavior of ILs using Electrospray Ionization Mass Spectrometry (ESI-MS). We have synthesized four hydrophilic ILs (1–4) and investigated their aggregation behavior and its impact on catalytic activity in Carbon-Carbon bond formation (Knoevenagel and Claisen-Schmidt condensation). Here, we show that the aggregation behavior of ILs depends on the type and nature of cation and anion. ESI-MS (?ve) spectra reveals two different type of aggregation i.e. [CnAn+1]? & [A2 + H+]?. We have found that catalytic activity increases with increased [CnAn+1]? supramolecular aggregation. Consequently, highest yield of products obtained in ILs which show decreased anion-anion aggregation [A2 + H+]? abundance in ESI-MS. We anticipate our results to be a starting point for the establishment of desired ILs for organic synthesis.

Introduction of a new bis-derivative of succinimide (Bis-Su) as a sustainable and efficient basic organo-catalyst for the synthesis of arylidene malononitrile and tetrahydrobenzo[b]pyran derivatives under green conditions

Organo-catalysts have been under great consideration for many years because of their performance and selectivity in the reactions. In this work, a new bis-succinimide (Bis-Su) compound is prepared, identified and used as a green and efficient basic organo