N-(2-methylcyclohexyl)-3-(3-((tetrahydro-2H-pyran-2-yloxy)methyl)-1,2,4-oxadiazol-5-yl)pyrrolo[1,2-b]pyridazin-4-amine

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Chemical Name:N-(2-methylcyclohexyl)-3-(3-((tetrahydro-2H-pyran-2-yloxy)methyl)-1,2,4-oxadiazol-5-yl)pyrrolo[1,2-b]pyridazin-4-amine
CAS No.:1263419-78-8
Molecular Formula:C₂₂H₂₉N₅O₃
Molecular Weight:411.504
Hs Code.:

Synonyms:N-(2-methylcyclohexyl)-3-(3-((tetrahydro-2H-pyran-2-yloxy)methyl)-1,2,4-oxadiazol-5-yl)pyrrolo[1,2-b]pyridazin-4-amine

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Chemical Property of N-(2-methylcyclohexyl)-3-(3-((tetrahydro-2H-pyran-2-yloxy)methyl)-1,2,4-oxadiazol-5-yl)pyrrolo[1,2-b]pyridazin-4-amine

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Technology Process of N-(2-methylcyclohexyl)-3-(3-((tetrahydro-2H-pyran-2-yloxy)methyl)-1,2,4-oxadiazol-5-yl)pyrrolo[1,2-b]pyridazin-4-amine

There total 7 articles about N-(2-methylcyclohexyl)-3-(3-((tetrahydro-2H-pyran-2-yloxy)methyl)-1,2,4-oxadiazol-5-yl)pyrrolo[1,2-b]pyridazin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1263419-77-7
methyl 4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-3-carboxylate

: 131041-99-1
N'-hydroxy-2-((tetrahydro-2H-pyran-2-yl)oxy)acetimidamide

: 1263419-78-8
N-(2-methylcyclohexyl)-3-(3-((tetrahydro-2H-pyran-2-yloxy)methyl)-1,2,4-oxadiazol-5-yl)pyrrolo[1,2-b]pyridazin-4-amine

Guidance literature:: N'-hydroxy-2-((tetrahydro-2H-pyran-2-yl)oxy)acetimidamide; With sodium hydride; In tetrahydrofuran; mineral oil; at 50 ℃; for 1h; Molecular sieve;

methyl 4-(2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-3-carboxylate; In tetrahydrofuran; mineral oil; for 19h; Reflux;

Reference yield:

: 628733-99-3
ethyl 1-amino-1H-pyrrole-2-carboxylate

: 1263419-78-8
N-(2-methylcyclohexyl)-3-(3-((tetrahydro-2H-pyran-2-yloxy)methyl)-1,2,4-oxadiazol-5-yl)pyrrolo[1,2-b]pyridazin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / ethanol; water / 18 h / Reflux

1.2: 1 h / 80 °C

1.3: pH 1

2.1: N,N-diethylaniline; trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 1 h / 80 °C

3.1: triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C

4.1: sodium hydroxide; ethanol / 14 h / Reflux

4.2: Acidic conditions

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 50 °C / Molecular sieve

6.2: 19 h / Reflux

With hydrogenchloride; dmap; ethanol; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1263419-99-3
4-hydroxypyrrolo[1,2-b]pyridazine-3-carbonitrile

: 1263419-78-8
N-(2-methylcyclohexyl)-3-(3-((tetrahydro-2H-pyran-2-yloxy)methyl)-1,2,4-oxadiazol-5-yl)pyrrolo[1,2-b]pyridazin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-diethylaniline; trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 1 h / 80 °C

2.1: triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C

3.1: sodium hydroxide; ethanol / 14 h / Reflux

3.2: Acidic conditions

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 50 °C / Molecular sieve

5.2: 19 h / Reflux

With dmap; ethanol; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; mineral oil;