8-(diphenyl-phosphinoyl)-7-methyl-7,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-6-one

Base Information

• Chemical Name: 8-(diphenyl-phosphinoyl)-7-methyl-7,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-6-one
• CAS No.: 750649-58-2
• Molecular Formula: C₂₂H₁₈NO₄P
• Molecular Weight: 391.363

Synonyms:8-(diphenyl-phosphinoyl)-7-methyl-7,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-6-one

Chemical Property of 8-(diphenyl-phosphinoyl)-7-methyl-7,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-6-one

Chemical Property:

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Technology Process of 8-(diphenyl-phosphinoyl)-7-methyl-7,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-6-one

There total 5 articles about 8-(diphenyl-phosphinoyl)-7-methyl-7,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-methoxy-benzo[1,3]dioxole-5-carboxylic acid (diphenyl-phosphinoylmethyl)-methyl-amide (750649-53-7) → 8-(diphenyl-phosphinoyl)-7-methyl-7,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-6-one (750649-58-2)

Guidance literature:

With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 - 20 ℃; for 2.25h;

DOI:10.1055/s-2004-829114

Reference yield:

4-methoxy-benzo[1,3]dioxole-5-carbonyl chloride (7169-10-0) → 8-(diphenyl-phosphinoyl)-7-methyl-7,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-6-one (750649-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂

2: 69 percent / KHMDS; 18-crown-6 / toluene; tetrahydrofuran / 2.25 h / -78 - 20 °C

With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1055/s-2004-829114

Reference yield:

4-methoxybenzo[d][1,3]dioxole-5-carbaldehyde (5779-99-7) → 8-(diphenyl-phosphinoyl)-7-methyl-7,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-6-one (750649-58-2)

Guidance literature:

Multi-step reaction with 4 steps

1: CrO₃; aq. H₂SO₄ / acetone

2: SOCl₂; DMF / CH₂Cl₂

3: CH₂Cl₂

4: 69 percent / KHMDS; 18-crown-6 / toluene; tetrahydrofuran / 2.25 h / -78 - 20 °C

With chromium(VI) oxide; thionyl chloride; 18-crown-6 ether; sulfuric acid; potassium hexamethylsilazane; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; acetone; toluene;

DOI:10.1055/s-2004-829114

upstream raw materials:

4-methoxy-benzo[1,3]dioxole-5-carboxylic acid (diphenyl-phosphinoylmethyl)-methyl-amide

4-methoxy-benzo[1,3]dioxole-5-carbonyl chloride

4-methoxybenzo[d][1,3]dioxole-5-carbaldehyde

2-methoxy-3,4-methylenedioxybenzoic acid

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