5779-99-7

Usage

Uses

Used in Pharmaceutical Industry:
4-Methoxy-1,3-benzodioxole-5-carbaldehyde is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of new drugs with potential therapeutic applications, making it a valuable component in the development of novel medications.
Used in Chemical Synthesis:
In the field of organic chemistry, 4-Methoxy-1,3-benzodioxole-5-carbaldehyde serves as a key intermediate for the synthesis of a wide range of chemical products. Its reactivity and functional groups enable the formation of various derivatives, which can be utilized in different applications, such as the production of specialty chemicals, dyes, and fragrances.
Used in Research and Development:
Due to its unique chemical properties, 4-Methoxy-1,3-benzodioxole-5-carbaldehyde is also used in research and development for the exploration of new chemical reactions and the discovery of novel compounds with potential applications in various industries, including pharmaceuticals, materials science, and environmental science.
Used in the Synthesis of Cotarnine Chloride:
4-Methoxy-1,3-benzodioxole-5-carbaldehyde is used as an intermediate in the synthesis of Cotarnine Chloride (C717500), which is an oxidative degradation product of the drug Noscapine (N882000). This application highlights the compound's importance in the pharmaceutical industry for the development of new drugs and drug candidates.

Upstream product

• 1817-95-4 4-methoxy-benzo[1,3]dioxole 
• 74-90-8 hydrogen cyanide 
• 68-12-2 N,N-dimethyl-formamide 
• 93-61-8 N-methyl-N-phenylformamide 
• 91129-06-5 2-Methoxy-3,4-(methylendioxy)benzaldehyde Cyclohexylimine 
• 934-00-9 3-methocycatechol 
• 74-95-3 1,1-dibromomethane 
• 10025-87-3 trichlorophosphate 
• 23780-59-8 4-hydroxybenzo[d][1,3]dioxole-5-carbaldehyde 
• 74-88-4 methyl iodide 
• 58343-44-5 2-Iodo-3,4-(methylendioxy)benzaldehyde cyclohexylimine 
• 77-78-1 dimethyl sulfate 
• 120-57-0 piperonal 
• 59259-90-4 5-(dimethoxymethyl)benzo[d][1,3]dioxole 

Downstream Products

• 88590-51-6 4-(4-methoxy-benzo[1,3]dioxol-5-ylmethylene)-2-phenyl-4H-oxazol-5-one 
• 484-32-2 2-methoxy-3,4-methylenedioxybenzoic acid 
• 750649-61-7 8-(Diphenyl-phosphinoyl)-7-(4-methoxy-benzyl)-7,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-6-one 
• 750649-58-2 8-(diphenyl-phosphinoyl)-7-methyl-7,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-6-one 
• 750649-53-7 4-methoxy-benzo[1,3]dioxole-5-carboxylic acid (diphenyl-phosphinoylmethyl)-methyl-amide 
• 750649-56-0 4-methoxy-benzo[1,3]dioxole-5-carboxylic acid (diphenyl-phosphinoylmethyl)-(4-methoxy-benzyl)-amide 
• 76965-90-7 7-benzyloxy-2'-methoxy-3',4'-methylenedioxyisoflavone 
• 477-82-7 evoxanthine 
• 550-10-7 hydrocotarnine 
• 5263-78-5 5,6,7,8-Tetrahydro-4-methoxy-1,3-dioxolo<4,5-g>isoquinoline 
• 82-54-2 4-methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-ol 
• 108434-79-3 5,6,7,8-Tetrahydro-8-acetoxy-4-methoxy-6-methyl-1,3-dioxolo<4,5-g>isoquinoline 
• 5985-55-7 Hydrocotarnine hydrochloride 
• 30936-27-7 4-methoxy-6-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium iodide 

Relevant academic research and scientific papers

A new total synthesis of (±)-α-noscapine

A new, convergent total synthesis of (±)-α-noscapine was developed on a grams scale through the condensation of 3-trimethylsilyl-meconin derivative 9 and the iodized salt cotarnine derivative 20 as the key step. Staring from simple 2,3-dimethoxybenzoic acid, piperonal and 2,2-dimethoxyethanamine, through the traditional chemical processes to give the final product in 11.6% yield over 14 steps.

Unnatural C-1 homologues of pancratistatin-Synthesis and promising biological activities

Several C-1 homologues of pancratistatin and 7-deoxypancratistatin were synthesized by a phenanthrene-phenathridone oxidative recyclization strategy. The key steps involved the enzymatic dihydroxylation of bromobenzene, addition of an aryl alane to an epo

Synthesis of C-1 homologues of pancratistatin and their preliminary biological evaluation

The synthesis of two C-1 analogues of pancratistatin has been accomplished in 17 steps from bromobenzene. The key steps involved the enzymatic dihydroxylation, regioselective opening of epoxyaziridine 9 with the alane derived from 8, a solid-state silica-

First total synthesis of (±)-powelline

The first total synthesis of (±)-powelline is reported in 10% overall yield over eight steps using an intramolecular oxidative phenolic coupling reaction as the key reaction.

A convenient synthesis of 4-alkoxylated isoindolin-1-ones

A short synthesis of 4-alkoxylated isoindolin-1-ones based upon the S NAr reaction applied to phosphorylated 2-methoxybenzamides followed by alkaline cleavage of the phosphoryl auxiliary is reported.

THE SYNTHESIS OF 6-METHOXY-7,8-METHYLENEDIOXYISOQUINOLINE DERIVATIVES

Several new 6-methoxy-7,8-methylenedioxyisoquinolines were synthesized starting from 4-methoxy-2,3-methylenedioxybenzaldehyde.

PREPARATION OF 2-METHOXY-3,4-METHYLENEDIOXYBENZALDEHYDE (CROWEACIN ALDEHYDE) FROM PYROGALLOL

2-Methoxy-3,4-methylenedioxybenzaldehyde (croweacin aldehyde) of high purity was prepared in 55percent overall yield from pyrogallol.

Synthesis of Cotarnin Iodide

Starting from 4-methoxy-1,3-benzodioxol-5-carbaldehyde (croweacin aldehyde, 3) a six-step synthesis of cotarnin iodide (9, 67percent total yield) is described. - Keywords.Croweacinaldehyde; Isoquinoline; Cotarnin iodide.

The Chemistry of 2H-3,1-Benzoxazine-2,4(1H)-dione (Isatoic Anhydride). 21. A Mild Process For The Preparation of 10-Alkyl-9-acridanones And It's Application To The Synthesis of Acridone Alkaloids

10-Substituted-9-acridanones are readily prepared by the reaction of the corresponding isatoic anhydride with the lithium enolate of 2-cyclohexen-1-one.The initially formed product, the 1,2-dihydroacridone need not be purified but can be aromatized directly with DDQ to the desired acridone.This methodology is applicable to the synthesis of acridone natural products.Two alkaloids, 1,2,3-trimethoxy-10-methylacridone (9) and evoxanthine (10), were prepared from 4,5,6-trimethoxy-N-methylisatoic anhydride and 6-methoxy-4,5-methylenedioxy-N-methylisatoic anhydride respectively.In these trioxygenated systems, palladium-on-charcoal must be used to aromatize the penultimate intermediate.