C₇₃H₁₂₄N₂O₇Si₃

Base Information

• Chemical Name: C₇₃H₁₂₄N₂O₇Si₃
• CAS No.: 1337879-24-9
• Molecular Formula: C₇₃H₁₂₄N₂O₇Si₃
• Molecular Weight: 1226.05
• Mol file: 1337879-24-9.mol

Synonyms:C₇₃H₁₂₄N₂O₇Si₃

Chemical Property of C₇₃H₁₂₄N₂O₇Si₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₇₃H₁₂₄N₂O₇Si₃

There total 15 articles about C₇₃H₁₂₄N₂O₇Si₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(3S,11bR)-3-amino-9,11-bis(benzyloxy)-2,3,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-4(11bH)-one (949463-54-1) + C46H98O5Si3 (1337879-11-4) → C73H124N2O7Si3 (1337879-24-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1016/j.tet.2011.07.085

Reference yield:

(+)-(3S,11bR)-3-(tert-butoxycarbonylamino)-9,11-dihydroxy-2,3,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-4(11bH)-one (949463-74-5) → C73H124N2O7Si3 (1337879-24-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

2.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

2.2: 20 °C

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 48 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; tetra-(n-butyl)ammonium iodide; caesium carbonate; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2011.07.085

Reference yield:

(+)-(3S,11bR)-3-(tert-butoxycarbonylamino)-9,11-bis(benzyloxy)-2,3,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-4(11bH)-one (949463-60-9) → C73H124N2O7Si3 (1337879-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

1.2: 20 °C

2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 48 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate;

DOI:10.1016/j.tet.2011.07.085

upstream raw materials:

(+)-(3S,11bR)-3-(tert-butoxycarbonylamino)-9,11-dihydroxy-2,3,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-4(11bH)-one

(+)-(3S,11bR)-3-(tert-butoxycarbonylamino)-9,11-bis(benzyloxy)-2,3,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-4(11bH)-one

(3S,11bR)-3-amino-9,11-bis(benzyloxy)-2,3,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-4(11bH)-one

C₄₆H₉₈O₅Si₃

Downstream raw materials:

(14S,17S,18S)-N-((3S,11bS)-9,11-bis(benzyloxy)-4-oxo-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-3-yl)-14,17,18-trihydroxyoctacosanamide