949463-54-1

Upstream product

• 949463-60-9 (+)-(3S,11bR)-3-(tert-butoxycarbonylamino)-9,11-bis(benzyloxy)-2,3,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-4(11bH)-one 
• 100-39-0 benzyl bromide 
• 5672-83-3 Z-L-GluOMe 
• 949463-56-3 methyl (S)-2-(benzyloxycarbonylamino)-5-(3,5-bis(benzyloxy)phenethylamino)-5-oxopentanoate 
• 949463-74-5 (+)-(3S,11bR)-3-(tert-butoxycarbonylamino)-9,11-dihydroxy-2,3,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-4(11bH)-one 
• 949463-58-5 benzyl (3S,11bR)-9,11-bis(benzyloxy)-4-oxo-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-3-ylcarbamate 
• 1384461-42-0 (S,E)-5-amino-9,11-bis(benzyloxy)-2,3,5,6-tetrahydrobenzo[d]azecin-4(1H)-one 
• 1384461-39-5 (R)-2-azido-1-(6,8-bis(benzyloxy)-1-vinyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone 
• 1384461-44-2 (R)-2-azido-1-(6,8-bis(benzyloxy)-1-(2-(2-nitrophenylselanyl)ethyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone 
• 1384461-38-4 (R)-2-azido-1-(6,8-bis(benzyloxy)-1-(2-hydroxyethyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone 
• 1384461-37-3 (R)-1-(1-allyl-6,8-bis(benzyloxy)-3,4-dihydroisoquinolin-2(1H)-yl)-2-azidoethanone 
• 1384461-43-1 C₂₇H₂₆N₄O₄ 
• 1384461-35-1 6,8-bis(benzyloxy)-3,4-dihydroisoquinoline 
• 1384461-36-2 C₂₆H₂₇NO₂ 

Downstream Products

• 949463-71-2 (S)-N-((3S,11bR)-9,11-bis(benzyloxy)-4-oxo-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-3-yl)-16-((4S,5S)-5-decyl-2,2-dimethyl-1,3-dioxolan-4-yl)-14-(methoxymethoxy)hexadecanamide 
• 949463-72-3 (14S,17S,18S)-N-((3S,11bS)-9,11-bis(benzyloxy)-4-oxo-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-3-yl)-14,17,18-trihydroxyoctacosanamide 
• 1127645-28-6 C₇₃H₁₂₄N₂O₇Si₃ 
• 1147745-31-0 (E,14S,20R)-N-((3S,11bR)-9,11-bis(benzyloxy)-2,3,4,6,7,11b-hexahydro-4-oxo-1H-pyrido[2,1-a]isoquinolin-3-yl)-14-hydroxy-20-methyloctacos-17-enamide 
• 1147745-22-9 (E,14S,20S)-N-((3S,11bR)-9,11-bis(benzyloxy)-2,3,4,6,7,11b-hexahydro-4-oxo-1H-pyrido[2,1-a]isoquinolin-3-yl)-14-hydroxy-20-methyloctacos-17-enamide 
• 1147745-88-7 2-((3S,11bR)-9,11-bis(benzyloxy)-2,3,4,6,7,11b-hexahydro-4-oxo-1H-pyrido[2,1-a]isoquinolin-3-yl)isoindoline-1,3-dione 
• 1147745-48-9 (2'R)-N-((3S,11bR)-9,11-bis(benzyloxy)-2,3,4,6,7,11b-hexahydro-4-oxo-1H-pyrido[2,1-a]isoquinolin-3-yl)-3',3',3'-trifluoro-2'-methoxy-2'-phenylpropanamide 
• 1147745-45-6 (2'S)-N-((3S,11bR)-9,11-bis(benzyloxy)-2,3,4,6,7,11b-hexahydro-4-oxo-1H-pyrido[2,1-a]isoquinolin-3-yl)-3',3',3'-trifluoro-2'-methoxy-2'-phenylpropanamide 
• 1337879-24-9 C₇₃H₁₂₄N₂O₇Si₃ 

Relevant academic research and scientific papers

Asymmetric formal synthesis of schulzeines A and C

The asymmetric formal synthesis of schulzeines A and C is described. Key features of the synthesis include the efficient and stereoselective construction of the benzoquinolizidine skeleton via the aza-Claisen rearrangement-induced ring expansion of the 1-

Formal synthesis of schulzeines B and C

A formal synthesis of schulzeines B and C, marine natural products with inhibitory effect against α-glucosidase, has been achieved. The key reactions of the synthesis are N-acyliminium ion cyclization, Sharpless asymmetric dihydroxylation, olefin cross me

Enantioselective synthesis of schulzeines B and C via a β-lactone-derived surrogate for bishomoserine aldehyde

Enantioselective syntheses of the glucosidase inhibitors schulzeines B and C were achieved by employing a Pictet-Spengler reaction of a β-lactone-derived, masked bishomoserine aldehyde. Subsequent Corey-Link reaction unveiled an α-azido acid enabling cycl

Total syntheses of schulzeines B and C

(Chemical Equation Presented) Schulzeines B (2) and C (3) were synthesized by a convergent strategy using epimeric tricyclic lactam building blocks, 4 and 5, and the C28 fatty acid side chain 6. Syntheses of tricyclic lactams (4/5) were achieved by Bischl