(3aR,4S,6aR,10R,10aR)-4-(2-Benzyloxy-ethyl)-10-methoxymethoxy-2,2-dimethyl-tetrahydro-1,3-dioxa-6,7-dithia-cyclopenta[d]naphthalene

Base Information

Chemical Name:(3aR,4S,6aR,10R,10aR)-4-(2-Benzyloxy-ethyl)-10-methoxymethoxy-2,2-dimethyl-tetrahydro-1,3-dioxa-6,7-dithia-cyclopenta[d]naphthalene
CAS No.:78442-73-6
Molecular Formula:C₂₂H₃₂O₅S₂
Molecular Weight:440.625
Hs Code.:

Synonyms:(3aR,4S,6aR,10R,10aR)-4-(2-Benzyloxy-ethyl)-10-methoxymethoxy-2,2-dimethyl-tetrahydro-1,3-dioxa-6,7-dithia-cyclopenta[d]naphthalene

Suppliers and Price of (3aR,4S,6aR,10R,10aR)-4-(2-Benzyloxy-ethyl)-10-methoxymethoxy-2,2-dimethyl-tetrahydro-1,3-dioxa-6,7-dithia-cyclopenta[d]naphthalene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3aR,4S,6aR,10R,10aR)-4-(2-Benzyloxy-ethyl)-10-methoxymethoxy-2,2-dimethyl-tetrahydro-1,3-dioxa-6,7-dithia-cyclopenta[d]naphthalene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3aR,4S,6aR,10R,10aR)-4-(2-Benzyloxy-ethyl)-10-methoxymethoxy-2,2-dimethyl-tetrahydro-1,3-dioxa-6,7-dithia-cyclopenta[d]naphthalene

There total 14 articles about (3aR,4S,6aR,10R,10aR)-4-(2-Benzyloxy-ethyl)-10-methoxymethoxy-2,2-dimethyl-tetrahydro-1,3-dioxa-6,7-dithia-cyclopenta[d]naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3S,4R,4aS,5R,8aR)-3-(2-Benzyloxy-ethyl)-5-methoxymethoxy-tetrahydro-thiopyrano[2,3-b]thiopyran-4,4a-diol

: 77-76-9
2,2-dimethoxy-propane

: 78442-73-6
(3aR,4S,6aR,10R,10aR)-4-(2-Benzyloxy-ethyl)-10-methoxymethoxy-2,2-dimethyl-tetrahydro-1,3-dioxa-6,7-dithia-cyclopenta[d]naphthalene

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 0 ℃; Yield given;
DOI:10.1021/ja00401a049

Reference yield:

: 31600-42-7
methyl 4-(benzyloxy)butanoate

: 78442-73-6
(3aR,4S,6aR,10R,10aR)-4-(2-Benzyloxy-ethyl)-10-methoxymethoxy-2,2-dimethyl-tetrahydro-1,3-dioxa-6,7-dithia-cyclopenta[d]naphthalene

Guidance literature:: Multi-step reaction with 13 steps

1: 1.) i-PrNLi / 1.) THF, -78 deg C

2: conc. H₂SO₄ / methanol / 25 °C

3: LiAlH₄ / diethyl ether / -20 deg C -> 0 deg C

4: pyridine / 0 °C

5: NaH / tetrahydrofuran; dimethylsulfoxide / Ambient temperature

6: AcOH / H₂O / Ambient temperature

7: SiO₂

8: pyridine / Ambient temperature

9: alumina / ethyl acetate / Ambient temperature

10: NaBH₄ / methanol / 0 °C

11: KH / tetrahydrofuran / 0 °C

12: 1.) OsO₄, 2.) NaHSO₃ / 1.) Et₂O, room temperature, 2.) aq. pyridine, room temperature

13: TsOH / CH₂Cl₂ / 0 °C

With pyridine; aluminum oxide; sodium tetrahydroborate; osmium(VIII) oxide; lithium aluminium tetrahydride; sulfuric acid; silica gel; potassium hydride; sodium hydride; toluene-4-sulfonic acid; sodium hydrogensulfite; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/ja00401a049

Reference yield:

: 10385-30-5
4-(benzyloxy)butanoic acid

: 78442-73-6
(3aR,4S,6aR,10R,10aR)-4-(2-Benzyloxy-ethyl)-10-methoxymethoxy-2,2-dimethyl-tetrahydro-1,3-dioxa-6,7-dithia-cyclopenta[d]naphthalene

Guidance literature:: Multi-step reaction with 14 steps

1: conc. H₂SO₄ / 25 °C

2: 1.) i-PrNLi / 1.) THF, -78 deg C

3: conc. H₂SO₄ / methanol / 25 °C

4: LiAlH₄ / diethyl ether / -20 deg C -> 0 deg C

5: pyridine / 0 °C

6: NaH / tetrahydrofuran; dimethylsulfoxide / Ambient temperature

7: AcOH / H₂O / Ambient temperature

8: SiO₂

9: pyridine / Ambient temperature

10: alumina / ethyl acetate / Ambient temperature

11: NaBH₄ / methanol / 0 °C

12: KH / tetrahydrofuran / 0 °C

13: 1.) OsO₄, 2.) NaHSO₃ / 1.) Et₂O, room temperature, 2.) aq. pyridine, room temperature

14: TsOH / CH₂Cl₂ / 0 °C

With pyridine; aluminum oxide; sodium tetrahydroborate; osmium(VIII) oxide; lithium aluminium tetrahydride; sulfuric acid; silica gel; potassium hydride; sodium hydride; toluene-4-sulfonic acid; sodium hydrogensulfite; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/ja00401a049