ethyl 5-(4-chloro-3-fluorobenzyl)oxazole-4-carboxylate

Base Information

• Chemical Name: ethyl 5-(4-chloro-3-fluorobenzyl)oxazole-4-carboxylate
• CAS No.: 1202897-24-2
• Molecular Formula: C₁₃H₁₁ClFNO₃
• Molecular Weight: 283.687
• Mol file: 1202897-24-2.mol

Synonyms:5-(4-chloro-3-fluoro-benzyl)-oxazole-4-carboxylic acid ethyl ester

Chemical Property of ethyl 5-(4-chloro-3-fluorobenzyl)oxazole-4-carboxylate

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

ethyl5-(4-chloro-3-fluorobenzyl)oxazole-4-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-(4-chloro-3-fluorobenzyl)oxazole-4-carboxylate

There total 1 articles about ethyl 5-(4-chloro-3-fluorobenzyl)oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.7%

Ethyl isocyanoacetate (2999-46-4) + 2-(4-chloro-3-fluorophenyl)acetyl chloride (1202897-23-1) → 5-(4-chloro-3-fluoro-benzyl)-oxazole-4-carboxylic acid ethyl ester (1202897-24-2)

Guidance literature:

Ethyl isocyanoacetate; With potassium tert-butylate; In tetrahydrofuran; at 5 ℃;

2-(4-chloro-3-fluorophenyl)acetyl chloride; In tetrahydrofuran; at 20 ℃;

Reference yield: 81.0%

5-(4-chloro-3-fluoro-benzyl)-oxazole-4-carboxylic acid ethyl ester (1202897-24-2) → 1-amino-3-(4-chloro-3-fluoro-phenyl)-propan-2-one monohydrochloride (1202897-25-3)

Guidance literature:

With hydrogenchloride; water; for 3h; Reflux;

upstream raw materials:

Ethyl isocyanoacetate

2-(4-chloro-3-fluorophenyl)acetyl chloride

Downstream raw materials:

1-amino-3-(4-chloro-3-fluoro-phenyl)-propan-2-one monohydrochloride