(Z)-7-[(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-(methyl-phenoxycarbonyl-amino)-cyclopentyl]-hept-5-enoic acid methyl ester

Base Information

• Chemical Name: (Z)-7-[(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-(methyl-phenoxycarbonyl-amino)-cyclopentyl]-hept-5-enoic acid methyl ester
• CAS No.: 85453-50-5
• Molecular Formula: C₄₇H₇₅NO₈SSi₂
• Molecular Weight: 870.351
• Mol file: 85453-50-5.mol

Synonyms:(Z)-7-[(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-(methyl-phenoxycarbonyl-amino)-cyclopentyl]-hept-5-enoic acid methyl ester

Chemical Property of (Z)-7-[(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-(methyl-phenoxycarbonyl-amino)-cyclopentyl]-hept-5-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-7-[(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-(methyl-phenoxycarbonyl-amino)-cyclopentyl]-hept-5-enoic acid methyl ester

There total 1 articles about (Z)-7-[(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-(methyl-phenoxycarbonyl-amino)-cyclopentyl]-hept-5-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(dimethylamino)-8-(phenylsulfonyl)-5,13-prostadienoate (77506-98-0) + phenyl chloroformate (1885-14-9) → (Z)-7-[(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-(methyl-phenoxycarbonyl-amino)-cyclopentyl]-hept-5-enoic acid methyl ester (85453-50-5)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; for 168h;

DOI:10.1021/jo00161a010

Reference yield: 100.0%

(Z)-7-[(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-(methyl-phenoxycarbonyl-amino)-cyclopentyl]-hept-5-enoic acid methyl ester (85453-50-5) → (Z)-7-[(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-(methyl-phenoxycarbonyl-amino)-cyclopentyl]-hept-5-enoic acid (85453-52-7)

Guidance literature:

With sodium hydroxide; In methanol; water;

DOI:10.1021/jo00161a010

upstream raw materials:

Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(dimethylamino)-8-(phenylsulfonyl)-5,13-prostadienoate

phenyl chloroformate

Downstream raw materials:

(Z)-7-[(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-(methyl-phenoxycarbonyl-amino)-cyclopentyl]-hept-5-enoic acid