1-(3,4-dimethoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-5,6,7-trimethoxyisoquinoline

Base Information

Chemical Name:1-(3,4-dimethoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-5,6,7-trimethoxyisoquinoline
CAS No.:74904-59-9
Molecular Formula:C₂₂H₂₉NO₅
Molecular Weight:387.476
Hs Code.:

Synonyms:1-(3,4-dimethoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-5,6,7-trimethoxyisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3,4-dimethoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-5,6,7-trimethoxyisoquinoline

Chemical Property:

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Technology Process of 1-(3,4-dimethoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-5,6,7-trimethoxyisoquinoline

There total 5 articles about 1-(3,4-dimethoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-5,6,7-trimethoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71561-48-3
1-(3,4-dimethoxybenzyl)-3,4-dihydro-2-methyl-5,6,7-trimethoxyisoquinolinium iodide

: 74904-59-9
1-(3,4-dimethoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-5,6,7-trimethoxyisoquinoline

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h; Yield given;
DOI:10.1016/S0040-4039(00)95777-0

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 74904-59-9
1-(3,4-dimethoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-5,6,7-trimethoxyisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / DCC, DMAP / acetonitrile / Ambient temperature

2: 82 percent / CH₂Cl₂ / 1 h / Ambient temperature

3: 1) POCl₃ / 1) CH₃CN, reflux, 3 h, 2) MeOH, reflux, 2 h

4: 0.75 g / NaBH₄ / methanol / 2 h / Ambient temperature

With dmap; sodium tetrahydroborate; dicyclohexyl-carbodiimide; trichlorophosphate; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(01)88259-4

Reference yield:

: 24237-31-8
N-<2-(2,3,4-trimethoxyphenyl)ethyl>-2-(3,4-dimethoxyphenyl)acetamide

: 74904-59-9
1-(3,4-dimethoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-5,6,7-trimethoxyisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 1) POCl₃ / 1) CH₃CN, reflux, 3 h, 2) MeOH, reflux, 2 h

2: 0.75 g / NaBH₄ / methanol / 2 h / Ambient temperature

With sodium tetrahydroborate; trichlorophosphate; In methanol;
DOI:10.1016/S0040-4020(01)88259-4