4-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyraldehyde

Base Information

• Chemical Name: 4-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyraldehyde
• CAS No.: 123002-57-3
• Molecular Formula: C₁₆H₂₆O₂Si
• Molecular Weight: 278.467
• Mol file: 123002-57-3.mol

Synonyms:4-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyraldehyde

Chemical Property of 4-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyraldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyraldehyde

There total 1 articles about 4-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldimethyl((1-phenylbut-3-yn-1-yl)oxy)silane (1000176-05-5) → 4-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyraldehyde (123002-57-3)

Guidance literature:

With water; [CpRu(η⁶-naphthalene]PF6; 6-tert-amyl-2-diphenylphosphinopyridine; In acetone; at 70 ℃; for 17h;

DOI:10.1055/s-2007-983884

Reference yield:

4-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyraldehyde (123002-57-3) + propynoic acid methyl ester (922-67-8) → 7-(tert-butyldimethylsilanyloxy)-4-hydroxy-7-phenylhept-2-ynoic acid methyl ester + 7-(tert-butyldimethylsilanyloxy)-4-hydroxy-7-phenylhept-2-ynoic acid methyl ester

Guidance literature:

propynoic acid methyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 0.333333h;

4-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyraldehyde; In tetrahydrofuran; at -78 ℃; for 0.0833333h; Further stages.;

DOI:10.1055/s-2007-983884

Reference yield:

4-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyraldehyde (123002-57-3) → 2-<(phenylthio)carbonyl>-5-phenyltetrahydrofuran (123002-75-5,123002-76-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) potassium tert-butoxide / 1.) tert-butyl alcohol, THF, 0 deg C, 15 min, 2.) tert-butyl alcohol, THF, RT

2: methanesulfonyl chloride, ethyldiisopropylamine / CH₂Cl₂ / 1.) -78 deg C, 10 min, 2.) -30 deg C, 10 min

With potassium tert-butylate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/jo00280a058

upstream raw materials:

tert-butyldimethyl((1-phenylbut-3-yn-1-yl)oxy)silane

Downstream raw materials:

2-<(phenylthio)carbonyl>-5-phenyltetrahydrofuran

1-<(tert-butyldimethylsilyl)oxy>-1-phenyl-5-nitro-5-(phenylthio)-(Z)-4-pentene